SNPH

Entrez Summary: N/A
UniProt Summary: Inhibits SNARE complex formation by absorbing free syntaxin-1. {ECO:0000269|PubMed:10707983}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

synaptic vesicle docking
syntaxin-1 binding
vesicle docking involved in exocytosis
cytoplasmic microtubule
vesicle docking
synaptic vesicle exocytosis
exocytic process
presynaptic membrane
neurotransmitter secretion
signal release from synapse
mitochondrial membrane
synaptic vesicle cycle
vesicle-mediated transport in synapse
signal release
organelle localization by membrane tethering
neurotransmitter transport
membrane docking
neuron projection
regulation of neurotransmitter levels
neuronal cell body
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling
synaptic signaling
cell junction
organelle localization
regulated exocytosis
brain development
head development
exocytosis
central nervous system development
secretion by cell
neuron differentiation
export from cell
cell-cell signaling
secretion
generation of neurons
neurogenesis
establishment of localization in cell
vesicle-mediated transport