SNX25

Gene Information

Official Symbol: SNX25
Official Name: sorting nexin 25
Aliases and Previous Symbols: N/A
Entrez ID: 83891
UniProt: Q9H3E2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in several stages of intracellular trafficking. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9584
Expression level (log2 read counts): 4.58

Expression Distribution

PX
PXA
RGS
Nexin C

type I transforming growth factor beta receptor binding
negative regulation of pathway-restricted SMAD protein phosphorylation
receptor catabolic process
regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
phosphatidylinositol binding
receptor metabolic process
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of cellular response to growth factor stimulus
endosome membrane
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
intracellular membrane-bounded organelle
molecular function
negative regulation of cellular protein metabolic process
macromolecule catabolic process
negative regulation of protein metabolic process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
protein transport
peptide transport
amide transport
regulation of phosphorylation
establishment of protein localization
negative regulation of response to stimulus
organic substance catabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
cellular catabolic process
nitrogen compound transport