SNX3 [The Human Chemical-Genetic Interaction Map Project]

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======= SNX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNX3
  * **<color #00a2e8>Official Name</color>**: sorting nexin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8724|8724]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60493|O60493]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605930|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intralumenal vesicle formation|
|negative regulation of cytoplasmic transport|
|negative regulation of early endosome to late endosome transport|
|protein to membrane docking|
|early phagosome|
|phosphatidylinositol-5-phosphate binding|
|regulation of early endosome to late endosome transport|
|negative regulation of viral entry into host cell|
|retromer complex|
|negative regulation of phagocytosis|
|regulation of cytoplasmic transport|
|phosphatidylinositol-3,5-bisphosphate binding|
|regulation of viral entry into host cell|
|phosphatidylinositol-4-phosphate binding|
|phosphatidylinositol-3-phosphate binding|
|clathrin-coated vesicle|
|negative regulation of intracellular transport|
|endosome organization|
|negative regulation of viral life cycle|
|protein phosphatase binding|
|regulation of phagocytosis|
|vesicle budding from membrane|
|negative regulation of viral process|
|negative regulation of protein catabolic process|
|regulation of viral life cycle|
|membrane invagination|
|early endosome membrane|
|membrane docking|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of viral process|
|endosome membrane|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|early endosome|
|positive regulation of neuron projection development|
|protein deubiquitination|
|protein modification by small protein removal|
|vesicle organization|
|negative regulation of catabolic process|
|regulation of intracellular transport|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of protein catabolic process|
|endomembrane system organization|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of neurogenesis|
|negative regulation of transport|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|regulation of neuron differentiation|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of multi-organism process|
|regulation of neurogenesis|
|membrane organization|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|regulation of protein localization|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|positive regulation of cellular component organization|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|protein transport|
|generation of neurons|
|peptide transport|
|amide transport|
|establishment of protein localization|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.06|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.7|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.76|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.79|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.82|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.88|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12205
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNX3 Expression in NALM6 Cells: 5.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>