SNX3

Entrez Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	-2.06
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.7
CyclicAMP 200μM R08 exp475	1.76
Hydroxychloroquine 30μM R08 exp490	1.79
FK-506 5μM R07 exp358	1.82
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.88
5-Fluorouracil 2μM R00 exp1	2.13

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

intralumenal vesicle formation
negative regulation of cytoplasmic transport
negative regulation of early endosome to late endosome transport
protein to membrane docking
early phagosome
phosphatidylinositol-5-phosphate binding
regulation of early endosome to late endosome transport
negative regulation of viral entry into host cell
retromer complex
negative regulation of phagocytosis
regulation of cytoplasmic transport
phosphatidylinositol-3,5-bisphosphate binding
regulation of viral entry into host cell
phosphatidylinositol-4-phosphate binding
phosphatidylinositol-3-phosphate binding
clathrin-coated vesicle
negative regulation of intracellular transport
endosome organization
negative regulation of viral life cycle
protein phosphatase binding
regulation of phagocytosis
vesicle budding from membrane
negative regulation of viral process
negative regulation of protein catabolic process
regulation of viral life cycle
membrane invagination
early endosome membrane
membrane docking
negative regulation of protein transport
negative regulation of establishment of protein localization
regulation of viral process
endosome membrane
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
early endosome
positive regulation of neuron projection development
protein deubiquitination
protein modification by small protein removal
vesicle organization
negative regulation of catabolic process