SNX4 [The Human Chemical-Genetic Interaction Map Project]

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======= SNX4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNX4
  * **<color #00a2e8>Official Name</color>**: sorting nexin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8723|8723]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95219|O95219]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNX4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNX4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605931|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. {ECO:0000269|PubMed:17994011}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leptin receptor binding|
|positive regulation of histamine secretion by mast cell|
|regulation of histamine secretion by mast cell|
|transferrin receptor binding|
|positive regulation of mast cell degranulation|
|positive regulation of mast cell activation involved in immune response|
|cytoplasmic dynein complex|
|positive regulation of mast cell activation|
|insulin receptor binding|
|positive regulation of leukocyte degranulation|
|positive regulation of myeloid leukocyte mediated immunity|
|epidermal growth factor receptor binding|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|endocytic recycling|
|positive regulation of neurotransmitter transport|
|regulation of mast cell activation|
|SNARE complex|
|regulation of leukocyte degranulation|
|positive regulation of regulated secretory pathway|
|regulation of myeloid leukocyte mediated immunity|
|phosphatidylinositol binding|
|positive regulation of exocytosis|
|positive regulation of hormone secretion|
|positive regulation of leukocyte mediated immunity|
|positive regulation of inflammatory response|
|regulation of neurotransmitter transport|
|early endosome membrane|
|regulation of regulated secretory pathway|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|positive regulation of immune effector process|
|regulation of exocytosis|
|endosomal transport|
|regulation of hormone secretion|
|positive regulation of ion transport|
|regulation of inflammatory response|
|regulation of intracellular transport|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of cell activation|
|positive regulation of secretion|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|protein-containing complex|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|regulation of ion transport|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|positive regulation of immune response|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.41|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.99|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.95|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.89|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.7|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.74|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8141
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNX4 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>