SNX4
Gene Information
- Official Symbol: SNX4
- Official Name: sorting nexin 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 8723
- UniProt: O95219
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. {ECO:0000269|PubMed:17994011}.
Pfam Domains GO Terms
Pfam Domains
| PX |
GO Terms
| leptin receptor binding |
| positive regulation of histamine secretion by mast cell |
| regulation of histamine secretion by mast cell |
| transferrin receptor binding |
| positive regulation of mast cell degranulation |
| positive regulation of mast cell activation involved in immune response |
| cytoplasmic dynein complex |
| positive regulation of mast cell activation |
| insulin receptor binding |
| positive regulation of leukocyte degranulation |
| positive regulation of myeloid leukocyte mediated immunity |
| epidermal growth factor receptor binding |
| regulation of mast cell degranulation |
| regulation of mast cell activation involved in immune response |
| endocytic recycling |
| positive regulation of neurotransmitter transport |
| regulation of mast cell activation |
| SNARE complex |
| regulation of leukocyte degranulation |
| positive regulation of regulated secretory pathway |
| regulation of myeloid leukocyte mediated immunity |
| phosphatidylinositol binding |
| positive regulation of exocytosis |
| positive regulation of hormone secretion |
| positive regulation of leukocyte mediated immunity |
| positive regulation of inflammatory response |
| regulation of neurotransmitter transport |
| early endosome membrane |
| regulation of regulated secretory pathway |
| regulation of leukocyte mediated immunity |
| positive regulation of intracellular transport |
| positive regulation of immune effector process |
| regulation of exocytosis |
| endosomal transport |
| regulation of hormone secretion |
| positive regulation of ion transport |
| regulation of inflammatory response |
| regulation of intracellular transport |
| positive regulation of leukocyte activation |
| positive regulation of secretion by cell |
| positive regulation of cell activation |
| positive regulation of secretion |
| regulation of immune effector process |
| positive regulation of defense response |
| regulation of hormone levels |
| regulation of vesicle-mediated transport |
| protein-containing complex |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| regulation of cell activation |
| regulation of ion transport |
| regulation of secretion by cell |
| regulation of defense response |
| regulation of secretion |
| positive regulation of immune response |
| regulation of cellular localization |
| positive regulation of transport |
| regulation of response to external stimulus |
| regulation of immune response |
| positive regulation of immune system process |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| establishment of protein localization |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| HMS-I2 5μM R06 exp287 | -2.41 |
| TGF-beta1 44ng/ml R08 exp528 | -1.99 |
| Wiskostatin 3μM R07 exp422 | -1.95 |
| Glyphosate 1000μM R06 exp283 | -1.89 |
| Selumetinib 20μM R02 exp81 | 1.7 |
| 5-Fluorouracil 20μM R00 exp2 | 1.74 |
| Bortezomib 0.05μM R00 exp7 | 1.85 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8141
- Expression level (log2 read counts): 5.37
Expression Distribution
SNX4 Expression in NALM6 Cells: 5.37
