SOCS1
Gene Information
- Official Symbol: SOCS1
- Official Name: suppressor of cytokine signaling 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8651
- UniProt: O15524
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. {ECO:0000250, ECO:0000269|PubMed:11278610, ECO:0000269|PubMed:11313480}.
Pfam Domains GO Terms
Pfam Domains
| SOCS box |
| SH2 |
GO Terms
| negative regulation of CD8-positive, alpha-beta T cell differentiation |
| kinase inhibitor activity |
| negative regulation of CD8-positive, alpha-beta T cell activation |
| regulation of CD8-positive, alpha-beta T cell differentiation |
| regulation of activation of Janus kinase activity |
| negative regulation of tyrosine phosphorylation of STAT protein |
| 1-phosphatidylinositol-3-kinase regulator activity |
| positive regulation of regulatory T cell differentiation |
| regulation of CD8-positive, alpha-beta T cell activation |
| insulin-like growth factor receptor binding |
| interleukin-7-mediated signaling pathway |
| phosphatidylinositol 3-kinase complex |
| negative regulation of receptor signaling pathway via JAK-STAT |
| negative regulation of receptor signaling pathway via STAT |
| negative regulation of alpha-beta T cell differentiation |
| regulation of response to interferon-gamma |
| regulation of interferon-gamma-mediated signaling pathway |
| protein kinase inhibitor activity |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| cellular response to interleukin-7 |
| response to interleukin-7 |
| regulation of regulatory T cell differentiation |
| negative regulation of insulin receptor signaling pathway |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| negative regulation of cellular response to insulin stimulus |
| receptor signaling pathway via JAK-STAT |
| negative regulation of alpha-beta T cell activation |
| receptor signaling pathway via STAT |
| negative regulation of T cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of alpha-beta T cell differentiation |
| phosphatidylinositol phosphorylation |
| negative regulation of peptidyl-tyrosine phosphorylation |
| regulation of phosphatidylinositol 3-kinase activity |
| negative regulation of lymphocyte differentiation |
| positive regulation of alpha-beta T cell activation |
| regulation of CD4-positive, alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| regulation of lipid kinase activity |
| regulation of insulin receptor signaling pathway |
| lipid phosphorylation |
| cytoplasmic ribonucleoprotein granule |
| cellular response to amino acid stimulus |
| regulation of cellular response to insulin stimulus |
| regulation of tyrosine phosphorylation of STAT protein |
| positive regulation of T cell differentiation |
| regulation of phospholipid metabolic process |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| negative regulation of leukocyte differentiation |
| fat cell differentiation |
| negative regulation of T cell activation |
| response to amino acid |
| negative regulation of leukocyte cell-cell adhesion |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of receptor signaling pathway via STAT |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| negative regulation of lymphocyte activation |
| positive regulation of leukocyte differentiation |
| regulation of cytokine-mediated signaling pathway |
| regulation of lymphocyte differentiation |
| phosphatidylinositol metabolic process |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| regulation of response to cytokine stimulus |
| positive regulation of hemopoiesis |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| lipid modification |
| regulation of cytokine secretion |
| cellular response to acid chemical |
| positive regulation of leukocyte cell-cell adhesion |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| regulation of peptidyl-tyrosine phosphorylation |
| cytoplasmic vesicle |
| positive regulation of cell-cell adhesion |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of transferase activity |
| regulation of leukocyte cell-cell adhesion |
| glycerophospholipid metabolic process |
| regulation of T cell activation |
| response to acid chemical |
| positive regulation of lymphocyte activation |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| regulation of lipid metabolic process |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| negative regulation of protein phosphorylation |
| positive regulation of cell activation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of hemopoiesis |
| regulation of innate immune response |
| protein kinase binding |
| regulation of protein secretion |
| regulation of peptide secretion |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| regulation of cell activation |
| cellular response to nitrogen compound |
| regulation of growth |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| protein ubiquitination |
| regulation of cytokine production |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of kinase activity |
| organophosphate metabolic process |
| negative regulation of developmental process |
| cellular lipid metabolic process |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| protein modification by small protein conjugation or removal |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| phosphorylation |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| PRIM1 | 0.567 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13637
- Expression level (log2 read counts): 0.69
Expression Distribution
SOCS1 Expression in NALM6 Cells: 0.69
