SOCS2 [The Human Chemical-Genetic Interaction Map Project]

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======= SOCS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOCS2
  * **<color #00a2e8>Official Name</color>**: suppressor of cytokine signaling 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8835|8835]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14508|O14508]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOCS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOCS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605117|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SOCS box|
|SH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|JAK pathway signal transduction adaptor activity|
|growth hormone receptor binding|
|negative regulation of multicellular organism growth|
|1-phosphatidylinositol-3-kinase regulator activity|
|insulin-like growth factor receptor binding|
|mammary gland alveolus development|
|mammary gland lobule development|
|interleukin-7-mediated signaling pathway|
|negative regulation of receptor signaling pathway via JAK-STAT|
|phosphatidylinositol 3-kinase complex|
|growth hormone receptor signaling pathway|
|negative regulation of receptor signaling pathway via STAT|
|cellular response to growth hormone stimulus|
|cellular response to interleukin-7|
|response to interleukin-7|
|negative regulation of insulin receptor signaling pathway|
|response to growth hormone|
|negative regulation of cellular response to insulin stimulus|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|lactation|
|phosphatidylinositol phosphorylation|
|SH3/SH2 adaptor activity|
|regulation of phosphatidylinositol 3-kinase activity|
|regulation of lipid kinase activity|
|regulation of insulin receptor signaling pathway|
|lipid phosphorylation|
|regulation of multicellular organism growth|
|regulation of cellular response to insulin stimulus|
|body fluid secretion|
|regulation of phospholipid metabolic process|
|negative regulation of developmental growth|
|mammary gland development|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|response to estradiol|
|phosphatidylinositol metabolic process|
|lipid modification|
|negative regulation of growth|
|cellular response to peptide hormone stimulus|
|glycerophospholipid metabolic process|
|cellular response to peptide|
|regulation of developmental growth|
|post-translational protein modification|
|positive regulation of neuron differentiation|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|gland development|
|regulation of cell growth|
|positive regulation of neurogenesis|
|response to peptide|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of growth|
|cytokine-mediated signaling pathway|
|protein ubiquitination|
|enzyme linked receptor protein signaling pathway|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|response to lipid|
|regulation of kinase activity|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|secretion|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.536|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12274
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOCS2 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>