SOCS2

Gene Information

Official Symbol: SOCS2
Official Name: suppressor of cytokine signaling 2
Aliases and Previous Symbols: N/A
Entrez ID: 8835
UniProt: O14508
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12274
Expression level (log2 read counts): 5.55

Expression Distribution

SOCS box
SH2

JAK pathway signal transduction adaptor activity
growth hormone receptor binding
negative regulation of multicellular organism growth
1-phosphatidylinositol-3-kinase regulator activity
insulin-like growth factor receptor binding
mammary gland alveolus development
mammary gland lobule development
interleukin-7-mediated signaling pathway
negative regulation of receptor signaling pathway via JAK-STAT
phosphatidylinositol 3-kinase complex
growth hormone receptor signaling pathway
negative regulation of receptor signaling pathway via STAT
cellular response to growth hormone stimulus
cellular response to interleukin-7
response to interleukin-7
negative regulation of insulin receptor signaling pathway
response to growth hormone
negative regulation of cellular response to insulin stimulus
receptor signaling pathway via JAK-STAT
receptor signaling pathway via STAT
lactation
phosphatidylinositol phosphorylation
SH3/SH2 adaptor activity
regulation of phosphatidylinositol 3-kinase activity
regulation of lipid kinase activity
regulation of insulin receptor signaling pathway
lipid phosphorylation
regulation of multicellular organism growth
regulation of cellular response to insulin stimulus
body fluid secretion
regulation of phospholipid metabolic process
negative regulation of developmental growth
mammary gland development
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
response to estradiol
phosphatidylinositol metabolic process
lipid modification
negative regulation of growth
cellular response to peptide hormone stimulus