SOCS6 [The Human Chemical-Genetic Interaction Map Project]

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======= SOCS6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOCS6
  * **<color #00a2e8>Official Name</color>**: suppressor of cytokine signaling 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9306|9306]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14544|O14544]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOCS6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOCS6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605118|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
|SOCS box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|1-phosphatidylinositol-3-kinase regulator activity|
|phosphatidylinositol 3-kinase complex|
|immunological synapse|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|phosphatidylinositol phosphorylation|
|regulation of phosphatidylinositol 3-kinase activity|
|regulation of lipid kinase activity|
|lipid phosphorylation|
|regulation of phospholipid metabolic process|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of lymphocyte activation|
|phosphatidylinositol metabolic process|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|negative regulation of cell activation|
|lipid modification|
|negative regulation of cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|glycerophospholipid metabolic process|
|regulation of T cell activation|
|proteasomal protein catabolic process|
|post-translational protein modification|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of lymphocyte activation|
|proteolysis involved in cellular protein catabolic process|
|regulation of leukocyte activation|
|cellular protein catabolic process|
|regulation of cell activation|
|regulation of growth|
|regulation of cell adhesion|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|regulation of kinase activity|
|organophosphate metabolic process|
|cellular macromolecule catabolic process|
|cellular lipid metabolic process|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|lipid metabolic process|
|negative regulation of signal transduction|
|proteolysis|
|phosphorylation|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|intracellular signal transduction|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11098
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOCS6 Expression in NALM6 Cells: -3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>