SOCS6

Entrez Summary: N/A
UniProt Summary: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SH2
SOCS box

1-phosphatidylinositol-3-kinase regulator activity
phosphatidylinositol 3-kinase complex
immunological synapse
receptor signaling pathway via JAK-STAT
receptor signaling pathway via STAT
phosphatidylinositol phosphorylation
regulation of phosphatidylinositol 3-kinase activity
regulation of lipid kinase activity
lipid phosphorylation
regulation of phospholipid metabolic process
negative regulation of T cell activation
negative regulation of leukocyte cell-cell adhesion
negative regulation of lymphocyte activation
phosphatidylinositol metabolic process
negative regulation of leukocyte activation
negative regulation of cell-cell adhesion
negative regulation of cell activation
lipid modification
negative regulation of cell adhesion
regulation of leukocyte cell-cell adhesion
glycerophospholipid metabolic process
regulation of T cell activation
proteasomal protein catabolic process
post-translational protein modification
phospholipid metabolic process
glycerolipid metabolic process
regulation of lipid metabolic process
regulation of cell-cell adhesion
negative regulation of immune system process
regulation of lymphocyte activation
proteolysis involved in cellular protein catabolic process
regulation of leukocyte activation
cellular protein catabolic process
regulation of cell activation
regulation of growth
regulation of cell adhesion
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
regulation of kinase activity