SOD1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SOD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOD1
  * **<color #00a2e8>Official Name</color>**: superoxide dismutase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6647|6647]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00441|P00441]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/147450|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sod Cu|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to antipsychotic drug|
|response to carbon monoxide|
|negative regulation of sterol biosynthetic process|
|negative regulation of cholesterol metabolic process|
|superoxide dismutase activity|
|negative regulation of cholesterol biosynthetic process|
|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|relaxation of vascular smooth muscle|
|peripheral nervous system myelin maintenance|
|protein phosphatase 2B binding|
|relaxation of smooth muscle|
|neurofilament cytoskeleton organization|
|hydrogen peroxide biosynthetic process|
|cellular response to potassium ion|
|auditory receptor cell stereocilium organization|
|antibiotic biosynthetic process|
|negative regulation of alcohol biosynthetic process|
|auditory receptor cell morphogenesis|
|removal of superoxide radicals|
|negative regulation of smooth muscle contraction|
|myelin maintenance|
|dense core granule|
|cellular response to oxygen radical|
|response to potassium ion|
|positive regulation of oxidative stress-induced cell death|
|cellular response to superoxide|
|superoxide anion generation|
|response to superoxide|
|positive regulation of cellular response to oxidative stress|
|retrograde axonal transport|
|cellular response to ATP|
|auditory receptor cell development|
|response to oxygen radical|
|positive regulation of superoxide anion generation|
|positive regulation of response to oxidative stress|
|relaxation of muscle|
|muscle cell cellular homeostasis|
|regulation of superoxide anion generation|
|negative regulation of steroid biosynthetic process|
|negative regulation of muscle contraction|
|regulation of T cell differentiation in thymus|
|reactive oxygen species biosynthetic process|
|negative regulation of steroid metabolic process|
|myelination in peripheral nervous system|
|inner ear auditory receptor cell differentiation|
|peripheral nervous system axon ensheathment|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|inner ear receptor cell stereocilium organization|
|Schwann cell development|
|vasodilation|
|response to ATP|
|dendrite cytoplasm|
|response to amphetamine|
|regulation of superoxide metabolic process|
|hair cell differentiation|
|Schwann cell differentiation|
|embryo implantation|
|cellular response to cadmium ion|
|hydrogen peroxide metabolic process|
|superoxide metabolic process|
|inner ear receptor cell development|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|neuroepithelial cell differentiation|
|anterograde axonal transport|
|thymus development|
|response to copper ion|
|response to amine|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|intermediate filament cytoskeleton organization|
|response to interleukin-12|
|columnar/cuboidal epithelial cell development|
|negative regulation of lipid biosynthetic process|
|response to axon injury|
|intermediate filament-based process|
|response to bronchodilator|
|ovarian follicle development|
|inner ear receptor cell differentiation|
|Rac GTPase binding|
|glutathione metabolic process|
|transmission of nerve impulse|
|axonal transport|
|regulation of cholesterol metabolic process|
|copper ion binding|
|axon cytoplasm|
|positive regulation of blood vessel diameter|
|mechanoreceptor differentiation|
|positive regulation of intrinsic apoptotic signaling pathway|
|regulation of smooth muscle contraction|
|cellular iron ion homeostasis|
|regulation of oxidative stress-induced cell death|
|cell aging|
|response to cadmium ion|
|regulation of multicellular organism growth|
|axo-dendritic transport|
|cellular response to nutrient|
|positive regulation of phagocytosis|
|regulation of mitochondrial membrane potential|
|peripheral nervous system development|
|regulation of alcohol biosynthetic process|
|retina homeostasis|
|regulation of cellular response to oxidative stress|
|mitochondrial intermembrane space|
|iron ion homeostasis|
|negative regulation of lipid metabolic process|
|regulation of response to oxidative stress|
|heart contraction|
|regulation of steroid biosynthetic process|
|female gonad development|
|cellular oxidant detoxification|
|negative regulation of small molecule metabolic process|
|development of primary female sexual characteristics|
|plasma membrane organization|
|regulation of organ growth|
|positive regulation of reactive oxygen species metabolic process|
|columnar/cuboidal epithelial cell differentiation|
|regulation of phagocytosis|
|inner ear morphogenesis|
|heart process|
|cellular detoxification|
|chaperone binding|
|antibiotic metabolic process|
|myelination|
|female sex differentiation|
|cellular transition metal ion homeostasis|
|glial cell development|
|myeloid cell homeostasis|
|ensheathment of neurons|
|peroxisome|
|axon ensheathment|
|response to heat|
|reactive oxygen species metabolic process|
|regulation of steroid metabolic process|
|ear morphogenesis|
|response to hydrogen peroxide|
|response to ethanol|
|detoxification|
|platelet degranulation|
|transition metal ion homeostasis|
|cellular response to reactive oxygen species|
|multicellular organismal signaling|
|response to organophosphorus|
|negative regulation of inflammatory response|
|regulation of T cell differentiation|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|negative regulation of neuron apoptotic process|
|sensory perception of sound|
|response to purine-containing compound|
|placenta development|
|activation of MAPK activity|
|transport along microtubule|
|regulation of muscle contraction|
|regulation of intrinsic apoptotic signaling pathway|
|sensory perception of mechanical stimulus|
|regulation of lymphocyte differentiation|
|vascular process in circulatory system|
|glial cell differentiation|
|positive regulation of apoptotic signaling pathway|
|cytoskeleton-dependent intracellular transport|
|response to temperature stimulus|
|regulation of reactive oxygen species metabolic process|
|female pregnancy|
|regulation of blood pressure|
|microtubule-based transport|
|regulation of lipid biosynthetic process|
|tissue homeostasis|
|epithelial cell development|
|cellular response to metal ion|
|inner ear development|
|locomotory behavior|
|response to reactive oxygen species|
|cellular modified amino acid metabolic process|
|homeostasis of number of cells|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|negative regulation of defense response|
|gonad development|
|multi-multicellular organism process|
|cofactor biosynthetic process|
|cellular response to toxic substance|
|gliogenesis|
|response to nutrient|
|development of primary sexual characteristics|
|cellular response to inorganic substance|
|ear development|
|response to alcohol|
|cellular response to nutrient levels|
|regulation of muscle system process|
|cellular response to oxidative stress|
|lysosome|
|cytoplasmic vesicle|
|sensory organ morphogenesis|
|positive regulation of MAP kinase activity|
|cellular response to extracellular stimulus|
|sex differentiation|
|microtubule-based movement|
|regulation of leukocyte differentiation|
|aging|
|embryonic organ morphogenesis|
|muscle system process|
|response to xenobiotic stimulus|
|response to antibiotic|
|regulation of neuron death|
|epidermal cell differentiation|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|activation of protein kinase activity|
|regulation of developmental growth|
|cellular response to external stimulus|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|regulation of MAP kinase activity|
|negative regulation of response to external stimulus|
|sulfur compound metabolic process|
|mitochondrial matrix|
|response to metal ion|
|neuronal cell body|
|response to oxidative stress|
|blood circulation|
|regulation of lipid metabolic process|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|gland development|
|epidermis development|
|endomembrane system organization|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|cofactor metabolic process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of GTPase activity|
|response to nutrient levels|
|drug metabolic process|
|response to toxic substance|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|peptide metabolic process|
|response to extracellular stimulus|
|response to inorganic substance|
|positive regulation of protein kinase activity|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|spermatogenesis|
|sensory organ development|
|regulation of vesicle-mediated transport|
|cellular metal ion homeostasis|
|cell morphogenesis involved in differentiation|
|male gamete generation|
|embryonic morphogenesis|
|response to wounding|
|behavior|
|positive regulation of kinase activity|
|regulation of system process|
|protein-containing complex|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|immune system development|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of growth|
|microtubule-based process|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|gamete generation|
|regulation of cytokine production|
|positive regulation of cell death|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|cell morphogenesis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of defense response|
|ion homeostasis|
|cellular amide metabolic process|
|exocytosis|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|membrane organization|
|regulation of kinase activity|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to organic cyclic compound|
|animal organ morphogenesis|
|oxidation-reduction process|
|sensory perception|
|regulation of transferase activity|
|embryo development|
|positive regulation of transport|
|multi-organism reproductive process|
|negative regulation of cell death|
|response to organonitrogen compound|
|secretion by cell|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|identical protein binding|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|chemical homeostasis|
|epithelium development|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|cell projection organization|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of hydrolase activity|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|intracellular transport|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-3.01|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-2.88|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.38|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.36|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.28|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.23|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.22|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2.07|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.03|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.01|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.99|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.97|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.89|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.87|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.86|
|[[:results:exp302|35°C R06 exp302]]|-1.85|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.82|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.76|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.74|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.74|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.71|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.71|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rtcb|RTCB]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 715/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|24/28|
|bone|26/26|
|breast|32/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|18/20|
|lung|72/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1360
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOD1 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>