SOD1
Gene Information
- Official Symbol: SOD1
- Official Name: superoxide dismutase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6647
- UniProt: P00441
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Sod Cu |
GO Terms
| response to antipsychotic drug |
| response to carbon monoxide |
| negative regulation of sterol biosynthetic process |
| negative regulation of cholesterol metabolic process |
| superoxide dismutase activity |
| negative regulation of cholesterol biosynthetic process |
| positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| relaxation of vascular smooth muscle |
| peripheral nervous system myelin maintenance |
| protein phosphatase 2B binding |
| relaxation of smooth muscle |
| neurofilament cytoskeleton organization |
| hydrogen peroxide biosynthetic process |
| cellular response to potassium ion |
| auditory receptor cell stereocilium organization |
| antibiotic biosynthetic process |
| negative regulation of alcohol biosynthetic process |
| auditory receptor cell morphogenesis |
| removal of superoxide radicals |
| negative regulation of smooth muscle contraction |
| myelin maintenance |
| dense core granule |
| cellular response to oxygen radical |
| response to potassium ion |
| positive regulation of oxidative stress-induced cell death |
| cellular response to superoxide |
| superoxide anion generation |
| response to superoxide |
| positive regulation of cellular response to oxidative stress |
| retrograde axonal transport |
| cellular response to ATP |
| auditory receptor cell development |
| response to oxygen radical |
| positive regulation of superoxide anion generation |
| positive regulation of response to oxidative stress |
| relaxation of muscle |
| muscle cell cellular homeostasis |
| regulation of superoxide anion generation |
| negative regulation of steroid biosynthetic process |
| negative regulation of muscle contraction |
| regulation of T cell differentiation in thymus |
| reactive oxygen species biosynthetic process |
| negative regulation of steroid metabolic process |
| myelination in peripheral nervous system |
| inner ear auditory receptor cell differentiation |
| peripheral nervous system axon ensheathment |
| regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| inner ear receptor cell stereocilium organization |
| Schwann cell development |
| vasodilation |
| response to ATP |
| dendrite cytoplasm |
| response to amphetamine |
| regulation of superoxide metabolic process |
| hair cell differentiation |
| Schwann cell differentiation |
| embryo implantation |
| cellular response to cadmium ion |
| hydrogen peroxide metabolic process |
| superoxide metabolic process |
| inner ear receptor cell development |
| regulation of sterol biosynthetic process |
| regulation of cholesterol biosynthetic process |
| neuroepithelial cell differentiation |
| anterograde axonal transport |
| thymus development |
| response to copper ion |
| response to amine |
| interleukin-12-mediated signaling pathway |
| cellular response to interleukin-12 |
| intermediate filament cytoskeleton organization |
| response to interleukin-12 |
| columnar/cuboidal epithelial cell development |
| negative regulation of lipid biosynthetic process |
| response to axon injury |
| intermediate filament-based process |
| response to bronchodilator |
| ovarian follicle development |
| inner ear receptor cell differentiation |
| Rac GTPase binding |
| glutathione metabolic process |
| transmission of nerve impulse |
| axonal transport |
| regulation of cholesterol metabolic process |
| copper ion binding |
| axon cytoplasm |
| positive regulation of blood vessel diameter |
| mechanoreceptor differentiation |
| positive regulation of intrinsic apoptotic signaling pathway |
| regulation of smooth muscle contraction |
| cellular iron ion homeostasis |
| regulation of oxidative stress-induced cell death |
| cell aging |
| response to cadmium ion |
| regulation of multicellular organism growth |
| axo-dendritic transport |
| cellular response to nutrient |
| positive regulation of phagocytosis |
| regulation of mitochondrial membrane potential |
| peripheral nervous system development |
| regulation of alcohol biosynthetic process |
| retina homeostasis |
| regulation of cellular response to oxidative stress |
| mitochondrial intermembrane space |
| iron ion homeostasis |
| negative regulation of lipid metabolic process |
| regulation of response to oxidative stress |
| heart contraction |
| regulation of steroid biosynthetic process |
| female gonad development |
| cellular oxidant detoxification |
| negative regulation of small molecule metabolic process |
| development of primary female sexual characteristics |
| plasma membrane organization |
| regulation of organ growth |
| positive regulation of reactive oxygen species metabolic process |
| columnar/cuboidal epithelial cell differentiation |
| regulation of phagocytosis |
| inner ear morphogenesis |
| heart process |
| cellular detoxification |
| chaperone binding |
| antibiotic metabolic process |
| myelination |
| female sex differentiation |
| cellular transition metal ion homeostasis |
| glial cell development |
| myeloid cell homeostasis |
| ensheathment of neurons |
| peroxisome |
| axon ensheathment |
| response to heat |
| reactive oxygen species metabolic process |
| regulation of steroid metabolic process |
| ear morphogenesis |
| response to hydrogen peroxide |
| response to ethanol |
| detoxification |
| platelet degranulation |
| transition metal ion homeostasis |
| cellular response to reactive oxygen species |
| multicellular organismal signaling |
| response to organophosphorus |
| negative regulation of inflammatory response |
| regulation of T cell differentiation |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| negative regulation of neuron apoptotic process |
| sensory perception of sound |
| response to purine-containing compound |
| placenta development |
| activation of MAPK activity |
| transport along microtubule |
| regulation of muscle contraction |
| regulation of intrinsic apoptotic signaling pathway |
| sensory perception of mechanical stimulus |
| regulation of lymphocyte differentiation |
| vascular process in circulatory system |
| glial cell differentiation |
| positive regulation of apoptotic signaling pathway |
| cytoskeleton-dependent intracellular transport |
| response to temperature stimulus |
| regulation of reactive oxygen species metabolic process |
| female pregnancy |
| regulation of blood pressure |
| microtubule-based transport |
| regulation of lipid biosynthetic process |
| tissue homeostasis |
| epithelial cell development |
| cellular response to metal ion |
| inner ear development |
| locomotory behavior |
| response to reactive oxygen species |
| cellular modified amino acid metabolic process |
| homeostasis of number of cells |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| negative regulation of defense response |
| gonad development |
| multi-multicellular organism process |
| cofactor biosynthetic process |
| cellular response to toxic substance |
| gliogenesis |
| response to nutrient |
| development of primary sexual characteristics |
| cellular response to inorganic substance |
| ear development |
| response to alcohol |
| cellular response to nutrient levels |
| regulation of muscle system process |
| cellular response to oxidative stress |
| lysosome |
| cytoplasmic vesicle |
| sensory organ morphogenesis |
| positive regulation of MAP kinase activity |
| cellular response to extracellular stimulus |
| sex differentiation |
| microtubule-based movement |
| regulation of leukocyte differentiation |
| aging |
| embryonic organ morphogenesis |
| muscle system process |
| response to xenobiotic stimulus |
| response to antibiotic |
| regulation of neuron death |
| epidermal cell differentiation |
| regulation of T cell activation |
| multicellular organismal homeostasis |
| activation of protein kinase activity |
| regulation of developmental growth |
| cellular response to external stimulus |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| anatomical structure homeostasis |
| regulation of MAP kinase activity |
| negative regulation of response to external stimulus |
| sulfur compound metabolic process |
| mitochondrial matrix |
| response to metal ion |
| neuronal cell body |
| response to oxidative stress |
| blood circulation |
| regulation of lipid metabolic process |
| circulatory system process |
| regulation of apoptotic signaling pathway |
| cellular response to drug |
| gland development |
| epidermis development |
| endomembrane system organization |
| reproductive structure development |
| regulation of small molecule metabolic process |
| reproductive system development |
| regulation of membrane potential |
| cell morphogenesis involved in neuron differentiation |
| embryonic organ development |
| cofactor metabolic process |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of GTPase activity |
| response to nutrient levels |
| drug metabolic process |
| response to toxic substance |
| regulation of lymphocyte activation |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| peptide metabolic process |
| response to extracellular stimulus |
| response to inorganic substance |
| positive regulation of protein kinase activity |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| spermatogenesis |
| sensory organ development |
| regulation of vesicle-mediated transport |
| cellular metal ion homeostasis |
| cell morphogenesis involved in differentiation |
| male gamete generation |
| embryonic morphogenesis |
| response to wounding |
| behavior |
| positive regulation of kinase activity |
| regulation of system process |
| protein-containing complex |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| metal ion homeostasis |
| cellular cation homeostasis |
| regulation of cell activation |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| immune system development |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| neuron projection development |
| developmental process involved in reproduction |
| regulation of growth |
| microtubule-based process |
| cytokine-mediated signaling pathway |
| epithelial cell differentiation |
| gamete generation |
| regulation of cytokine production |
| positive regulation of cell death |
| regulated exocytosis |
| cation homeostasis |
| inorganic ion homeostasis |
| cell morphogenesis |
| regulation of cellular response to stress |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| regulation of defense response |
| ion homeostasis |
| cellular amide metabolic process |
| exocytosis |
| regulation of protein kinase activity |
| neuron development |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| zinc ion binding |
| multicellular organism reproduction |
| membrane organization |
| regulation of kinase activity |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| response to organic cyclic compound |
| animal organ morphogenesis |
| oxidation-reduction process |
| sensory perception |
| regulation of transferase activity |
| embryo development |
| positive regulation of transport |
| multi-organism reproductive process |
| negative regulation of cell death |
| response to organonitrogen compound |
| secretion by cell |
| cellular response to cytokine stimulus |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| export from cell |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| response to nitrogen compound |
| regulation of response to external stimulus |
| response to cytokine |
| cytoskeleton organization |
| chemical homeostasis |
| epithelium development |
| secretion |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| response to abiotic stimulus |
| cell projection organization |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| mitochondrion |
| regulation of hydrolase activity |
| nervous system process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| intracellular transport |
| generation of neurons |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| extracellular region |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RTCB | 0.403 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 715/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 24/28 |
| bone | 26/26 |
| breast | 32/33 |
| central nervous system | 54/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 15/16 |
| kidney | 21/21 |
| liver | 18/20 |
| lung | 72/75 |
| lymphocyte | 15/16 |
| ovary | 26/26 |
| pancreas | 23/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 13/15 |
| prostate | 0/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 1360
- Expression level (log2 read counts): 7.01
Expression Distribution
SOD1 Expression in NALM6 Cells: 7.01
