SOGA2

Entrez Summary: N/A
UniProt Summary: Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. {ECO:0000269|PubMed:23902687}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bortezomib 0.05μM R00 exp7	-1.95
Doxycycline 10μM R00 exp18	-1.78

positive regulation of microtubule motor activity
microtubule bundle
regulation of microtubule motor activity
apicolateral plasma membrane
positive regulation of protein targeting to membrane
regulation of protein targeting to membrane
establishment or maintenance of epithelial cell apical/basal polarity
establishment or maintenance of bipolar cell polarity
establishment or maintenance of apical/basal cell polarity
lateral plasma membrane
regulation of protein targeting
microtubule bundle formation
positive regulation of protein localization to membrane
spindle pole
positive regulation of intracellular protein transport
midbody
regulation of protein localization to membrane
establishment or maintenance of cell polarity
positive regulation of intracellular transport
regulation of intracellular protein transport
microtubule binding
apical plasma membrane
positive regulation of cellular protein localization
regulation of autophagy
regulation of intracellular transport
cytoskeleton
positive regulation of protein transport
positive regulation of establishment of protein localization
microtubule cytoskeleton organization
regulation of cellular protein localization
microtubule-based process
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
positive regulation of hydrolase activity
regulation of cellular catabolic process
protein homodimerization activity
regulation of cellular localization
positive regulation of transport
regulation of catabolic process