SORD

Entrez Summary: N/A
UniProt Summary: Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. {ECO:0000250|UniProtKB:Q64442, ECO:0000269|PubMed:16278369}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ADH N
ADH zinc N

L-xylitol metabolic process
pentitol catabolic process
sorbitol catabolic process
(R,R)-butanediol dehydrogenase activity
D-xylulose reductase activity
L-iditol 2-dehydrogenase activity
ribitol 2-dehydrogenase activity
L-xylitol catabolic process
hexitol catabolic process
pentitol metabolic process
sorbitol metabolic process
fructose biosynthetic process
hexitol metabolic process
xylulose 5-phosphate biosynthetic process
glucuronate catabolic process
xylulose 5-phosphate metabolic process
glucuronate catabolic process to xylulose 5-phosphate
alditol catabolic process
fructose metabolic process
glucuronate metabolic process
uronic acid metabolic process
alditol metabolic process
polyol catabolic process
cellular carbohydrate catabolic process
NAD binding
response to copper ion
hexose biosynthetic process
monosaccharide biosynthetic process
alcohol catabolic process
monosaccharide catabolic process
response to cadmium ion
flagellated sperm motility
sperm motility
organic hydroxy compound catabolic process
response to osmotic stress
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
motile cilium
mitochondrial membrane
polyol metabolic process