SOX1

Entrez Summary: N/A
UniProt Summary: Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HMG box
SOXp

cell fate specification involved in pattern specification
ventral spinal cord interneuron specification
ventral spinal cord interneuron fate commitment
cell fate commitment involved in pattern specification
ventral spinal cord interneuron differentiation
spinal cord dorsal/ventral patterning
lens morphogenesis in camera-type eye
nuclear transcription factor complex
spinal cord patterning
forebrain neuron development
neuron fate specification
ventral spinal cord development
forebrain neuron differentiation
cell differentiation in spinal cord
neuron fate commitment
forebrain generation of neurons
lens development in camera-type eye
central nervous system neuron development
dorsal/ventral pattern formation
cell fate specification
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
spinal cord development
camera-type eye morphogenesis
neuron migration
eye morphogenesis
central nervous system neuron differentiation
cell fate commitment
sensory organ morphogenesis
camera-type eye development
regionalization
eye development
visual system development
sensory system development
forebrain development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
sensory organ development
DNA-binding transcription factor activity