SOX5

Entrez Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of mesenchymal stem cell differentiation
regulation of mesenchymal stem cell differentiation
asymmetric neuroblast division
asymmetric stem cell division
neuronal stem cell division
neuroblast division
asymmetric cell division
positive regulation of chondrocyte differentiation
positive regulation of stem cell differentiation
somatic stem cell division
neuroblast proliferation
stem cell division
positive regulation of cartilage development
regulation of chondrocyte differentiation
stem cell proliferation
regulation of cartilage development
neural precursor cell proliferation
regulation of stem cell differentiation
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
cell fate commitment
transcription by RNA polymerase II
cell division
cellular response to growth factor stimulus
response to growth factor
cell population proliferation
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
positive regulation of cell differentiation
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process