SP1 [The Human Chemical-Genetic Interaction Map Project]

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======= SP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SP1
  * **<color #00a2e8>Official Name</color>**: Sp1 transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6667|6667]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08047|P08047]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/189906|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21798247}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of phenotypic switching by transcription from RNA polymerase II promoter|
|regulation of hydrogen sulfide biosynthetic process|
|positive regulation of hydrogen sulfide biosynthetic process|
|positive regulation of sulfur metabolic process|
|positive regulation of secondary metabolite biosynthetic process|
|regulation of phenotypic switching|
|regulation of secondary metabolite biosynthetic process|
|regulation of secondary metabolic process|
|regulation of sulfur metabolic process|
|positive regulation of vascular endothelial cell proliferation|
|HMG box domain binding|
|positive regulation by host of viral transcription|
|regulation of vascular endothelial cell proliferation|
|response to hydroperoxide|
|bHLH transcription factor binding|
|histone acetyltransferase binding|
|proximal promoter sequence-specific DNA binding|
|RNA polymerase II repressing transcription factor binding|
|repressing transcription factor binding|
|positive regulation of viral transcription|
|regulation of sterol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|protein-DNA complex|
|positive regulation of blood vessel endothelial cell migration|
|regulation of cholesterol metabolic process|
|transcriptional repressor complex|
|regulation of viral transcription|
|snRNA transcription by RNA polymerase II|
|modification by host of symbiont morphology or physiology|
|snRNA transcription|
|regulation of alcohol biosynthetic process|
|interaction with symbiont|
|regulation of steroid biosynthetic process|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell proliferation|
|ncRNA transcription|
|positive regulation of endothelial cell migration|
|double-stranded DNA binding|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|histone deacetylase binding|
|regulation of steroid metabolic process|
|regulation of endothelial cell proliferation|
|positive regulation of epithelial cell migration|
|modification of morphology or physiology of other organism|
|regulation of endothelial cell migration|
|cellular response to insulin stimulus|
|positive regulation of angiogenesis|
|positive regulation of vasculature development|
|regulation of lipid biosynthetic process|
|positive regulation of epithelial cell proliferation|
|protein C-terminus binding|
|regulation of viral process|
|transcription regulatory region DNA binding|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of epithelial cell migration|
|response to insulin|
|nuclear chromatin|
|cellular response to peptide hormone stimulus|
|rhythmic process|
|regulation of angiogenesis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of vasculature development|
|cellular response to peptide|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|response to oxidative stress|
|response to peptide hormone|
|regulation of lipid metabolic process|
|sequence-specific DNA binding|
|regulation of small molecule metabolic process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|response to peptide|
|transcription by RNA polymerase II|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of multi-organism process|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|DNA-binding transcription factor activity|
|viral process|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell migration|
|protein homodimerization activity|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|DNA binding|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.78|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.92|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.93|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.94|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.02|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.06|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.09|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.14|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.29|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.49|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.74|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.04|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|3.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1300
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SP1 Expression in NALM6 Cells: 7.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>