SP1

Gene Information

Official Symbol: SP1
Official Name: Sp1 transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 6667
UniProt: P08047
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014].
UniProt Summary: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1. {ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615, ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115, ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997, ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555, ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680, ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490, ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796, ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21798247}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 2μM R05 exp210	1.78
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.92
Vinblastine 0.002μM R01 exp60	1.93
Dinaciclib 0.007μM R07 exp355	1.94
Trimetrexate 0.03μM R08 exp535	2.02
Lead acetate 2000μM R08 exp498 no dilution day6	2.06
Bortezomib 0.005μM R00 exp6	2.09
Vincristine 0.0005μM R04 exp190	2.14
Quercetin 20μM R08 exp517	2.29
TRAIL 5ng/ml R00 exp35	2.49
3-Bromopyruvate 7μM R04 exp175	2.74
TRAIL 50ng/ml R00 exp36	3.04
Q15 2.7μM R02 exp79	3.05

Global Fraction of Cell Lines Where Essential: 10/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1300
Expression level (log2 read counts): 7.26

Expression Distribution

regulation of phenotypic switching by transcription from RNA polymerase II promoter
regulation of hydrogen sulfide biosynthetic process
positive regulation of hydrogen sulfide biosynthetic process
positive regulation of sulfur metabolic process
positive regulation of secondary metabolite biosynthetic process
regulation of phenotypic switching
regulation of secondary metabolite biosynthetic process
regulation of secondary metabolic process
regulation of sulfur metabolic process
positive regulation of vascular endothelial cell proliferation
HMG box domain binding
positive regulation by host of viral transcription
regulation of vascular endothelial cell proliferation
response to hydroperoxide
bHLH transcription factor binding
histone acetyltransferase binding
proximal promoter sequence-specific DNA binding
RNA polymerase II repressing transcription factor binding
repressing transcription factor binding
positive regulation of viral transcription
regulation of sterol biosynthetic process
regulation of cholesterol biosynthetic process
protein-DNA complex
positive regulation of blood vessel endothelial cell migration
regulation of cholesterol metabolic process
transcriptional repressor complex
regulation of viral transcription
snRNA transcription by RNA polymerase II
modification by host of symbiont morphology or physiology
snRNA transcription
regulation of alcohol biosynthetic process
interaction with symbiont
regulation of steroid biosynthetic process
regulation of blood vessel endothelial cell migration
positive regulation of endothelial cell proliferation
ncRNA transcription
positive regulation of endothelial cell migration
double-stranded DNA binding
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction