SPA17

Entrez Summary: N/A
UniProt Summary: Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sperm fibrous sheath
sperm principal piece
epithelial cilium movement involved in extracellular fluid movement
extracellular transport
binding of sperm to zona pellucida
sperm-egg recognition
cilium movement
cell-cell recognition
motile cilium
single fertilization
fertilization
microtubule-based transport
cilium
calmodulin binding
cell recognition
microtubule-based movement
external side of plasma membrane
spermatogenesis
male gamete generation
microtubule-based process
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
reproductive process
reproduction
movement of cell or subcellular component
extracellular region