SPACA3

Entrez Summary: N/A
UniProt Summary: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. {ECO:0000269|PubMed:12606493}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

acrosomal matrix
lysozyme activity
monocyte activation
fusion of sperm to egg plasma membrane involved in single fertilization
acrosomal membrane
plasma membrane fusion
positive regulation of macrophage activation
sperm-egg recognition
regulation of macrophage activation
positive regulation of phagocytosis
cell-cell recognition
defense response to Gram-negative bacterium
secretory granule
defense response to Gram-positive bacterium
regulation of phagocytosis
membrane fusion
single fertilization
fertilization
cell recognition
defense response to bacterium
cellular process involved in reproduction in multicellular organism
positive regulation of leukocyte activation
positive regulation of cell activation
regulation of vesicle-mediated transport
myeloid leukocyte activation
regulation of leukocyte activation
regulation of cell activation
response to bacterium
sexual reproduction
multicellular organism reproduction
membrane organization
leukocyte activation
defense response to other organism
positive regulation of transport
multi-organism reproductive process
cell activation
positive regulation of immune system process
response to other organism
response to external biotic stimulus
response to biotic stimulus