SPAG9 [The Human Chemical-Genetic Interaction Map Project]

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======= SPAG9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPAG9
  * **<color #00a2e8>Official Name</color>**: sperm associated antigen 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9043|9043]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60271|O60271]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPAG9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPAG9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Jnk-SapK ap N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MAP-kinase scaffold activity|
|JUN kinase binding|
|receptor signaling complex adaptor activity|
|activation of JUN kinase activity|
|kinesin binding|
|lysosome localization|
|positive regulation of JUN kinase activity|
|JNK cascade|
|positive regulation of muscle cell differentiation|
|regulation of JUN kinase activity|
|acrosomal vesicle|
|retrograde transport, endosome to Golgi|
|stress-activated MAPK cascade|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|cytosolic transport|
|regulation of muscle cell differentiation|
|activation of MAPK activity|
|microtubule organizing center|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of JNK cascade|
|striated muscle cell differentiation|
|endosomal transport|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|muscle cell differentiation|
|positive regulation of MAP kinase activity|
|lysosomal membrane|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|protein homooligomerization|
|regulation of MAP kinase activity|
|positive regulation of neuron differentiation|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|positive regulation of neurogenesis|
|muscle structure development|
|positive regulation of cell migration|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|organelle localization|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|perinuclear region of cytoplasm|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|intracellular transport|
|generation of neurons|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.71|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.74|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6792
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPAG9 Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>