SPAG9

Entrez Summary: This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Pyridostatin 4μM R05 exp240	1.71
Ammonium tetrathiomolybdate 10μM R08 exp448	1.74
S-DABN 8μM R03 exp112	1.9

MAP-kinase scaffold activity
JUN kinase binding
receptor signaling complex adaptor activity
activation of JUN kinase activity
kinesin binding
lysosome localization
positive regulation of JUN kinase activity
JNK cascade
positive regulation of muscle cell differentiation
regulation of JUN kinase activity
acrosomal vesicle
retrograde transport, endosome to Golgi
stress-activated MAPK cascade
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
cytosolic transport
regulation of muscle cell differentiation
activation of MAPK activity
microtubule organizing center
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
striated muscle cell differentiation
endosomal transport
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
muscle cell differentiation
positive regulation of MAP kinase activity
lysosomal membrane
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
protein homooligomerization
regulation of MAP kinase activity
positive regulation of neuron differentiation
MAPK cascade
signal transduction by protein phosphorylation
positive regulation of neurogenesis
muscle structure development
positive regulation of cell migration
regulation of protein serine/threonine kinase activity