SPDYA

Entrez Summary: N/A
UniProt Summary: Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T- loop that obstructs the substrate-binding cleft prior to kinase activation (PubMed:28666995). Mediates cell survival during the DNA damage process through activation of CDK2 (PubMed:12839962). {ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12839962, ECO:0000269|PubMed:12972555, ECO:0000269|PubMed:28666995}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein kinase activator activity
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of cyclin-dependent protein kinase activity
male meiotic nuclear division
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
meiotic nuclear division
meiotic cell cycle process
meiotic cell cycle
mitotic cell cycle phase transition
cell cycle phase transition
nuclear division
organelle fission
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
cellular process involved in reproduction in multicellular organism
positive regulation of cell cycle
protein kinase binding
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
male gamete generation
positive regulation of kinase activity
mitotic cell cycle process
positive regulation of transferase activity
mitotic cell cycle
gamete generation
cellular response to DNA damage stimulus
regulation of protein kinase activity
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
regulation of kinase activity
positive regulation of cell population proliferation
regulation of transferase activity
multi-organism reproductive process
cell cycle process
positive regulation of protein phosphorylation
positive regulation of phosphorylation