SPHK1
Gene Information
- Official Symbol: SPHK1
- Official Name: sphingosine kinase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8877
- UniProt: Q9NYA1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N- dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. {ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:23602659}.
Pfam Domains GO Terms
Pfam Domains
| DAGK cat |
GO Terms
| sphingoid catabolic process |
| regulation of endosomal vesicle fusion |
| sphinganine kinase activity |
| D-erythro-sphingosine kinase activity |
| negative regulation of sphingolipid biosynthetic process |
| negative regulation of ceramide biosynthetic process |
| sphingosine-1-phosphate receptor activity |
| sphingosine-1-phosphate receptor signaling pathway |
| sphingolipid mediated signaling pathway |
| sphingosine biosynthetic process |
| sphingoid biosynthetic process |
| sphingosine metabolic process |
| regulation of ceramide biosynthetic process |
| regulation of membrane lipid metabolic process |
| sphingoid metabolic process |
| regulation of sphingolipid biosynthetic process |
| NAD+ kinase activity |
| regulation of microglial cell activation |
| positive regulation of interleukin-17 production |
| diol biosynthetic process |
| acetyltransferase activity |
| diol metabolic process |
| positive regulation of p38MAPK cascade |
| regulation of interleukin-17 production |
| positive regulation of peptidyl-threonine phosphorylation |
| regulation of vesicle fusion |
| positive regulation of smooth muscle contraction |
| regulation of neuroinflammatory response |
| sphingolipid catabolic process |
| protein phosphatase 2A binding |
| membrane lipid catabolic process |
| cellular response to vascular endothelial growth factor stimulus |
| regulation of p38MAPK cascade |
| regulation of peptidyl-threonine phosphorylation |
| positive regulation of muscle contraction |
| negative regulation of lipid biosynthetic process |
| positive regulation of fibroblast proliferation |
| regulation of macrophage activation |
| positive regulation of mitotic nuclear division |
| clathrin-coated pit |
| regulation of tumor necrosis factor-mediated signaling pathway |
| endocytic vesicle |
| polyol biosynthetic process |
| regulation of smooth muscle contraction |
| lipid phosphorylation |
| positive regulation of nuclear division |
| cellular response to hydrogen peroxide |
| positive regulation of NIK/NF-kappaB signaling |
| regulation of fibroblast proliferation |
| regulation of interleukin-1 beta production |
| negative regulation of lipid metabolic process |
| sphingolipid biosynthetic process |
| regulation of interleukin-1 production |
| presynapse |
| regulation of phagocytosis |
| regulation of NIK/NF-kappaB signaling |
| DNA biosynthetic process |
| polyol metabolic process |
| alcohol biosynthetic process |
| positive regulation of protein ubiquitination |
| cellular response to antibiotic |
| response to hydrogen peroxide |
| membrane lipid biosynthetic process |
| cellular response to reactive oxygen species |
| positive regulation of protein modification by small protein conjugation or removal |
| protein acetylation |
| calcium-mediated signaling |
| negative regulation of cellular amide metabolic process |
| positive regulation of mitotic cell cycle |
| positive regulation of NF-kappaB transcription factor activity |
| early endosome membrane |
| sphingolipid metabolic process |
| lipid binding |
| regulation of muscle contraction |
| regulation of cytokine-mediated signaling pathway |
| positive regulation of angiogenesis |
| positive regulation of cell growth |
| positive regulation of stress-activated MAPK cascade |
| regulation of mitotic nuclear division |
| positive regulation of stress-activated protein kinase signaling cascade |
| regulation of response to cytokine stimulus |
| positive regulation of vasculature development |
| organic hydroxy compound biosynthetic process |
| regulation of lipid biosynthetic process |
| protein acylation |
| regulation of nuclear division |
| ammonium ion metabolic process |
| response to reactive oxygen species |
| cellular lipid catabolic process |
| regulation of protein ubiquitination |
| lipid modification |
| calmodulin binding |
| membrane lipid metabolic process |
| regulation of endocytosis |
| cellular response to toxic substance |
| magnesium ion binding |
| regulation of protein modification by small protein conjugation or removal |
| protein folding |
| regulation of stress-activated MAPK cascade |
| regulation of muscle system process |
| regulation of stress-activated protein kinase signaling cascade |
| cellular response to oxidative stress |
| positive regulation of growth |
| positive regulation of DNA-binding transcription factor activity |
| response to tumor necrosis factor |
| positive regulation of cell cycle process |
| regulation of angiogenesis |
| lipid catabolic process |
| response to antibiotic |
| alcohol metabolic process |
| regulation of vasculature development |
| second-messenger-mediated signaling |
| regulation of inflammatory response |
| positive regulation of cell cycle |
| response to oxidative stress |
| regulation of lipid metabolic process |
| cellular response to drug |
| regulation of cellular amide metabolic process |
| regulation of cell growth |
| regulation of DNA-binding transcription factor activity |
| positive regulation of cytokine production |
| organic hydroxy compound metabolic process |
| blood vessel development |
| inflammatory response |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| response to toxic substance |
| vasculature development |
| cardiovascular system development |
| positive regulation of cell motility |
| response to growth factor |
| response to inorganic substance |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| cell junction |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| lipid biosynthetic process |
| regulation of system process |
| small molecule biosynthetic process |
| regulation of leukocyte activation |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| regulation of cell activation |
| regulation of growth |
| regulation of cytokine production |
| regulation of cellular response to stress |
| brain development |
| DNA metabolic process |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| regulation of defense response |
| head development |
| regulation of cell migration |
| circulatory system development |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| cellular lipid metabolic process |
| regulation of cellular component biogenesis |
| central nervous system development |
| regulation of locomotion |
| negative regulation of cell death |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| organonitrogen compound catabolic process |
| regulation of response to external stimulus |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| lipid metabolic process |
| positive regulation of protein modification process |
| phosphorylation |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| G protein-coupled receptor signaling pathway |
| defense response |
| positive regulation of developmental process |
| organonitrogen compound biosynthetic process |
| regulation of protein phosphorylation |
| DNA binding |
| regulation of response to stress |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| QNZ 0.01μM R05 exp241 | -1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11766
- Expression level (log2 read counts): 0.77
Expression Distribution
SPHK1 Expression in NALM6 Cells: 0.77
