SPHK2 [The Human Chemical-Genetic Interaction Map Project]

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======= SPHK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPHK2
  * **<color #00a2e8>Official Name</color>**: sphingosine kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56848|56848]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRA0|Q9NRA0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPHK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPHK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607092|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides. {ECO:0000269|PubMed:19168031}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAGK cat|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H2B-K12 acetylation|
|sphinganine-1-phosphate biosynthetic process|
|interleukin-13 secretion|
|histone H2A-K5 acetylation|
|D-erythro-sphingosine kinase activity|
|sphinganine kinase activity|
|negative regulation of histone deacetylase activity|
|sphinganine-1-phosphate metabolic process|
|negative regulation of deacetylase activity|
|tumor necrosis factor secretion|
|histone H2B acetylation|
|interleukin-13 production|
|cytokine secretion involved in immune response|
|interleukin-6 secretion|
|nucleosomal histone binding|
|regulation of cytochrome-c oxidase activity|
|response to phorbol 13-acetate 12-myristate|
|cellular response to phorbol 13-acetate 12-myristate|
|negative regulation of histone deacetylation|
|regulation of electron transfer activity|
|tumor necrosis factor production|
|positive regulation of histone H3-K9 acetylation|
|sphingosine-1-phosphate receptor activity|
|regulation of histone deacetylase activity|
|tumor necrosis factor superfamily cytokine production|
|positive regulation of ceramide biosynthetic process|
|positive regulation of protein kinase C signaling|
|positive regulation of sphingolipid biosynthetic process|
|sphingosine-1-phosphate receptor signaling pathway|
|interleukin-6 production|
|regulation of deacetylase activity|
|sphingosine biosynthetic process|
|sphingolipid mediated signaling pathway|
|sphingoid biosynthetic process|
|sphingosine metabolic process|
|Ras GTPase binding|
|regulation of histone H3-K9 acetylation|
|positive regulation of mast cell activation involved in immune response|
|positive regulation of mast cell degranulation|
|regulation of protein kinase C signaling|
|regulation of sphingolipid biosynthetic process|
|regulation of membrane lipid metabolic process|
|regulation of ceramide biosynthetic process|
|sphingoid metabolic process|
|NAD+ kinase activity|
|histone H2A acetylation|
|regulation of ATP biosynthetic process|
|diol biosynthetic process|
|positive regulation of calcium ion import|
|positive regulation of mast cell activation|
|diol metabolic process|
|regulation of proton transport|
|cytokine production involved in immune response|
|positive regulation of leukocyte degranulation|
|regulation of histone deacetylation|
|positive regulation of histone acetylation|
|positive regulation of myeloid leukocyte mediated immunity|
|positive regulation of peptidyl-lysine acetylation|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|regulation of calcium ion import|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|negative regulation of histone modification|
|positive regulation of protein acetylation|
|regulation of protein deacetylation|
|regulation of mast cell activation|
|cytokine secretion|
|regulation of leukocyte degranulation|
|positive regulation of regulated secretory pathway|
|regulation of histone acetylation|
|regulation of myeloid leukocyte mediated immunity|
|polyol biosynthetic process|
|negative regulation of chromatin organization|
|regulation of peptidyl-lysine acetylation|
|positive regulation of gene expression, epigenetic|
|lipid phosphorylation|
|nucleosome|
|regulation of protein acetylation|
|positive regulation of lipid biosynthetic process|
|cellular response to alcohol|
|regulation of reactive oxygen species biosynthetic process|
|positive regulation of exocytosis|
|positive regulation of histone modification|
|sphingolipid biosynthetic process|
|cellular response to ketone|
|response to antineoplastic agent|
|regulation of oxidoreductase activity|
|positive regulation of chromatin organization|
|polyol metabolic process|
|alcohol biosynthetic process|
|histone acetylation|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|internal peptidyl-lysine acetylation|
|regulation of ATP metabolic process|
|peptidyl-lysine acetylation|
|positive regulation of calcium ion transport|
|internal protein amino acid acetylation|
|membrane lipid biosynthetic process|
|positive regulation of leukocyte mediated immunity|
|negative regulation of chromosome organization|
|positive regulation of lipid metabolic process|
|protein acetylation|
|regulation of histone modification|
|cytokine production|
|positive regulation of cellular amide metabolic process|
|sphingolipid metabolic process|
|protein secretion|
|regulation of generation of precursor metabolites and energy|
|establishment of protein localization to extracellular region|
|regulation of regulated secretory pathway|
|protein localization to extracellular region|
|peptide secretion|
|positive regulation of chromosome organization|
|regulation of reactive oxygen species metabolic process|
|production of molecular mediator of immune response|
|female pregnancy|
|negative regulation of cell growth|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|protein acylation|
|regulation of chromatin organization|
|ammonium ion metabolic process|
|response to ketone|
|lipid modification|
|membrane lipid metabolic process|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|multi-multicellular organism process|
|positive regulation of immune effector process|
|regulation of exocytosis|
|response to alcohol|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of gene expression, epigenetic|
|negative regulation of growth|
|phospholipid biosynthetic process|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|lysosomal membrane|
|peptidyl-lysine modification|
|alcohol metabolic process|
|regulation of cation transmembrane transport|
|regulation of chromosome organization|
|regulation of intracellular transport|
|histone modification|
|negative regulation of organelle organization|
|phospholipid metabolic process|
|covalent chromatin modification|
|regulation of metal ion transport|
|mitochondrial inner membrane|
|regulation of lipid metabolic process|
|regulation of cellular amide metabolic process|
|positive regulation of secretion by cell|
|cellular response to drug|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of cell growth|
|regulation of small molecule metabolic process|
|positive regulation of secretion|
|negative regulation of hydrolase activity|
|organic hydroxy compound metabolic process|
|regulation of immune effector process|
|regulation of ion transmembrane transport|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|organophosphate biosynthetic process|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|regulation of transmembrane transport|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|chromatin organization|
|regulation of ion transport|
|negative regulation of cellular component organization|
|brain development|
|regulation of secretion by cell|
|head development|
|negative regulation of catalytic activity|
|regulation of secretion|
|response to lipid|
|positive regulation of immune response|
|circulatory system development|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|central nervous system development|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|secretion by cell|
|endoplasmic reticulum|
|response to drug|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|chromosome organization|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|ATP binding|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.71|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6085
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPHK2 Expression in NALM6 Cells: 4.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>