SPIDR [The Human Chemical-Genetic Interaction Map Project]

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======= SPIDR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPIDR
  * **<color #00a2e8>Official Name</color>**: scaffold protein involved in DNA repair
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23514|23514]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14159|Q14159]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPIDR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPIDR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615384|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity. {ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to camptothecin|
|response to camptothecin|
|cellular response to hydroxyurea|
|regulation of establishment of protein localization to chromosome|
|response to hydroxyurea|
|response to antimetabolite|
|nuclear chromosome|
|positive regulation of double-strand break repair|
|cellular response to alkaloid|
|regulation of double-strand break repair via homologous recombination|
|positive regulation of DNA repair|
|cellular response to ionizing radiation|
|regulation of double-strand break repair|
|cellular response to alcohol|
|response to antineoplastic agent|
|double-strand break repair via homologous recombination|
|positive regulation of response to DNA damage stimulus|
|recombinational repair|
|regulation of DNA recombination|
|response to alkaloid|
|regulation of DNA repair|
|response to ionizing radiation|
|cellular response to radiation|
|double-strand break repair|
|positive regulation of DNA metabolic process|
|regulation of response to DNA damage stimulus|
|cellular response to inorganic substance|
|DNA recombination|
|response to alcohol|
|positive regulation of protein complex assembly|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of DNA metabolic process|
|cellular response to drug|
|response to radiation|
|regulation of protein complex assembly|
|DNA repair|
|positive regulation of cellular component biogenesis|
|response to inorganic substance|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of establishment of protein localization|
|cellular response to DNA damage stimulus|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|response to organonitrogen compound|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|cellular response to stress|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-3.96|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.73|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.67|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.54|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.02|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.9|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.79|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:swsap1|SWSAP1]]|0.546|
|[[:human genes:m:mcm9|MCM9]]|0.484|
|[[:human genes:r:rnf168|RNF168]]|0.47|
|[[:human genes:s:sfr1|SFR1]]|0.458|
|[[:human genes:h:h2afx|H2AFX]]|0.449|
|[[:human genes:z:zswim7|ZSWIM7]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6125
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPIDR Expression in NALM6 Cells: 5.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>