SPINK6

Entrez Summary: N/A
UniProt Summary: Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8. {ECO:0000269|PubMed:20667819, ECO:0000269|PubMed:21439340}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Kazal 1
Kazal 2

negative regulation of serine-type endopeptidase activity
negative regulation of serine-type peptidase activity
regulation of serine-type endopeptidase activity
regulation of serine-type peptidase activity
serine-type endopeptidase inhibitor activity
cornification
keratinization
negative regulation of endopeptidase activity
negative regulation of peptidase activity
keratinocyte differentiation
epidermal cell differentiation
negative regulation of proteolysis
skin development
epidermis development
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
epithelial cell differentiation
regulation of proteolysis
negative regulation of catalytic activity
central nervous system development
negative regulation of cellular protein metabolic process
programmed cell death
cell death
negative regulation of protein metabolic process
epithelium development
negative regulation of molecular function
regulation of hydrolase activity
tissue development
extracellular region