SPINK9

Entrez Summary: N/A
UniProt Summary: Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5. {ECO:0000269|PubMed:19190773, ECO:0000269|PubMed:19194479}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Torin1 0.08μM R02 exp82	-1.92
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.7

Kazal 2
Kazal 1

serine-type endopeptidase inhibitor activity
cornification
keratinization
negative regulation of endopeptidase activity
negative regulation of peptidase activity
keratinocyte differentiation
epidermal cell differentiation
negative regulation of proteolysis
skin development
epidermis development
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
epithelial cell differentiation
regulation of proteolysis
negative regulation of catalytic activity
negative regulation of cellular protein metabolic process
programmed cell death
cell death
negative regulation of protein metabolic process
epithelium development
negative regulation of molecular function
regulation of hydrolase activity
tissue development
extracellular region