SPIRE1

Entrez Summary: N/A
UniProt Summary: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

formin-nucleated actin cable assembly
formin-nucleated actin cable organization
polar body extrusion after meiotic divisions
establishment of meiotic spindle localization
cleavage furrow formation
parallel actin filament bundle assembly
meiotic cytokinesis
positive regulation of double-strand break repair
female meiotic nuclear division
actin nucleation
cytokinetic process
establishment of spindle localization
spindle localization
cleavage furrow
actin filament bundle assembly
actin filament bundle organization
positive regulation of DNA repair
regulation of double-strand break repair
positive regulation of actin filament polymerization
cytoskeleton-dependent cytokinesis
positive regulation of response to DNA damage stimulus
cytokinesis
regulation of DNA repair
positive regulation of protein polymerization
female gamete generation
cell cortex
plasma membrane invagination
cytoplasmic vesicle membrane
membrane invagination
meiotic nuclear division
regulation of actin filament polymerization
meiotic cell cycle process
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of DNA metabolic process
positive regulation of supramolecular fiber organization
regulation of response to DNA damage stimulus
positive regulation of cytoskeleton organization
meiotic cell cycle
regulation of protein polymerization