SPNS2

Entrez Summary: N/A
UniProt Summary: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration. {ECO:0000269|PubMed:19074308}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MFS 1
Sugar tr

sphingolipid transporter activity
regulation of eye pigmentation
sphingosine-1-phosphate receptor signaling pathway
sphingolipid mediated signaling pathway
regulation of developmental pigmentation
lymph node development
B cell homeostasis
T cell homeostasis
lymphocyte homeostasis
lymphocyte migration
leukocyte homeostasis
regulation of humoral immune response
sphingolipid metabolic process
bone development
homeostasis of number of cells
membrane lipid metabolic process
lipid transport
lipid localization
leukocyte migration
skeletal system development
hematopoietic or lymphoid organ development
immune system development
cellular lipid metabolic process
cell migration
cell motility
localization of cell
regulation of immune response
lipid metabolic process
transmembrane transport
locomotion
G protein-coupled receptor signaling pathway
movement of cell or subcellular component
homeostatic process
regulation of immune system process