SPOCK2

Official Symbol: SPOCK2
Official Name: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
Aliases and Previous Symbols: N/A
Entrez ID: 9806
UniProt: Q92563
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: May participate in diverse steps of neurogenesis. Binds calcium.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
metalloendopeptidase inhibitor activity
glycosaminoglycan binding
extracellular matrix binding
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan metabolic process
peptide cross-linking
collagen binding
proteoglycan metabolic process
synapse assembly
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
mucopolysaccharide metabolic process
positive regulation of cell-substrate adhesion
glycosaminoglycan metabolic process
aminoglycan metabolic process
peptidyl-serine modification
regulation of cell-substrate adhesion
extracellular matrix
negative regulation of endopeptidase activity
negative regulation of peptidase activity
synapse organization
extracellular matrix organization
negative regulation of proteolysis
sulfur compound metabolic process
glycoprotein metabolic process
extracellular structure organization
positive regulation of cell adhesion
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
regulation of cell adhesion
calcium ion binding
regulation of proteolysis
negative regulation of catalytic activity
peptidyl-amino acid modification
regulation of cell motility