SPOCK3

Official Symbol: SPOCK3
Official Name: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
Aliases and Previous Symbols: N/A
Entrez ID: 50859
UniProt: Q9BQ16
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
metalloendopeptidase inhibitor activity
glycosaminoglycan binding
extracellular matrix binding
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan metabolic process
peptide cross-linking
collagen binding
proteoglycan metabolic process
mucopolysaccharide metabolic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
peptidyl-serine modification
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
negative regulation of proteolysis
sulfur compound metabolic process
glycoprotein metabolic process
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
calcium ion binding
regulation of proteolysis
negative regulation of catalytic activity
peptidyl-amino acid modification
regulation of cell motility
regulation of locomotion
regulation of cellular component movement
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
extracellular space
small molecule metabolic process