SPON2 [The Human Chemical-Genetic Interaction Map Project]

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======= SPON2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPON2
  * **<color #00a2e8>Official Name</color>**: spondin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10417|10417]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BUD6|Q9BUD6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPON2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPON2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605918|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spond N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|induction of bacterial agglutination|
|positive regulation of macrophage cytokine production|
|opsonization|
|regulation of macrophage cytokine production|
|mast cell mediated immunity|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|lipopolysaccharide binding|
|defense response to fungus|
|antibacterial humoral response|
|response to fungus|
|positive regulation of cytokine production involved in immune response|
|regulation of cytokine production involved in immune response|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of interleukin-6 production|
|positive regulation of production of molecular mediator of immune response|
|antimicrobial humoral response|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|antigen binding|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|defense response to virus|
|cellular response to biotic stimulus|
|positive regulation of immune effector process|
|extracellular matrix|
|response to virus|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|phagocytosis|
|defense response to bacterium|
|humoral immune response|
|positive regulation of cytokine production|
|regulation of immune effector process|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|response to bacterium|
|regulation of cytokine production|
|innate immune response|
|leukocyte mediated immunity|
|response to lipid|
|positive regulation of immune response|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cellular response to oxygen-containing compound|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to oxygen-containing compound|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3177
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPON2 Expression in NALM6 Cells: 1.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>