SPON2

Gene Information

Official Symbol: SPON2
Official Name: spondin 2
Aliases and Previous Symbols: N/A
Entrez ID: 10417
UniProt: Q9BUD6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3177
Expression level (log2 read counts): 1.75

Expression Distribution

induction of bacterial agglutination
positive regulation of macrophage cytokine production
opsonization
regulation of macrophage cytokine production
mast cell mediated immunity
positive regulation of myeloid leukocyte cytokine production involved in immune response
lipopolysaccharide binding
defense response to fungus
antibacterial humoral response
response to fungus
positive regulation of cytokine production involved in immune response
regulation of cytokine production involved in immune response
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
positive regulation of interleukin-6 production
positive regulation of production of molecular mediator of immune response
antimicrobial humoral response
regulation of interleukin-6 production
regulation of production of molecular mediator of immune response
antigen binding
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
defense response to virus
cellular response to biotic stimulus
positive regulation of immune effector process
extracellular matrix
response to virus
response to lipopolysaccharide
response to molecule of bacterial origin
phagocytosis
defense response to bacterium
humoral immune response
positive regulation of cytokine production
regulation of immune effector process
myeloid leukocyte mediated immunity
cellular response to lipid
response to bacterium
regulation of cytokine production