SPP2

Entrez Summary: This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008].
UniProt Summary: Could coordinate an aspect of bone turnover. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

platelet dense granule lumen
endopeptidase inhibitor activity
bone remodeling
tissue remodeling
platelet degranulation
negative regulation of endopeptidase activity
negative regulation of peptidase activity
endoplasmic reticulum lumen
negative regulation of proteolysis
post-translational protein modification
collagen-containing extracellular matrix
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
skeletal system development
regulated exocytosis
regulation of proteolysis
negative regulation of catalytic activity
exocytosis
secretion by cell
negative regulation of cellular protein metabolic process
export from cell
negative regulation of protein metabolic process
secretion
negative regulation of molecular function
regulation of hydrolase activity
extracellular region
vesicle-mediated transport