SPRED3

Gene Information

Official Symbol: SPRED3
Official Name: sprouty related EVH1 domain containing 3
Aliases and Previous Symbols: N/A
Entrez ID: 399473
UniProt: Q2MJR0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13409
Expression level (log2 read counts): 2.75

Expression Distribution

Sprouty
WH1

positive regulation of DNA damage response, signal transduction by p53 class mediator
negative regulation of peptidyl-threonine phosphorylation
positive regulation of signal transduction by p53 class mediator
inactivation of MAPK activity
regulation of DNA damage response, signal transduction by p53 class mediator
regulation of protein deacetylation
regulation of peptidyl-threonine phosphorylation
negative regulation of MAP kinase activity
positive regulation of response to DNA damage stimulus
negative regulation of protein serine/threonine kinase activity
negative regulation of MAPK cascade
regulation of signal transduction by p53 class mediator
regulation of response to DNA damage stimulus
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
regulation of MAP kinase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
protein kinase binding
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of cellular response to stress
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
positive regulation of intracellular signal transduction
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
regulation of response to stress