SPRR2E
Gene Information
- Official Symbol: SPRR2E
- Official Name: small proline rich protein 2E
- Aliases and Previous Symbols: N/A
- Entrez ID: 6704
- UniProt: P22531
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014].
- UniProt Summary: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2420
- Expression level (log2 read counts): -6.6
SPRR2E Expression in NALM6 Cells: -6.6
