SPRY3

Gene Information

Official Symbol: SPRY3
Official Name: sprouty RTK signaling antagonist 3
Aliases and Previous Symbols: N/A
Entrez ID: 10251
UniProt: O43610
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7552
Expression level (log2 read counts): 2.06

Expression Distribution

negative regulation of fibroblast growth factor receptor signaling pathway
regulation of fibroblast growth factor receptor signaling pathway
negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
negative regulation of MAP kinase activity
negative regulation of protein serine/threonine kinase activity
negative regulation of cellular response to growth factor stimulus
negative regulation of MAPK cascade
negative regulation of protein kinase activity
regulation of Ras protein signal transduction
negative regulation of kinase activity
regulation of cellular response to growth factor stimulus
negative regulation of transferase activity
regulation of MAP kinase activity
regulation of small GTPase mediated signal transduction
negative regulation of protein phosphorylation
axon development
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
neuron projection development
regulation of MAPK cascade
molecular function
negative regulation of catalytic activity
regulation of protein kinase activity
neuron development
regulation of kinase activity
regulation of transferase activity
neuron differentiation
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
plasma membrane bounded cell projection organization
negative regulation of molecular function
cell projection organization
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling