SPRY4

Gene Information

Official Symbol: SPRY4
Official Name: sprouty RTK signaling antagonist 4
Aliases and Previous Symbols: N/A
Entrez ID: 81848
UniProt: Q9C004
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014].
UniProt Summary: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1. {ECO:0000269|PubMed:12717443}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16891
Expression level (log2 read counts): 0.69

Expression Distribution

negative regulation of fibroblast growth factor receptor signaling pathway
regulation of fibroblast growth factor receptor signaling pathway
negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
negative regulation of ERK1 and ERK2 cascade
negative regulation of MAP kinase activity
ruffle membrane
negative regulation of protein serine/threonine kinase activity
negative regulation of cellular response to growth factor stimulus
negative regulation of MAPK cascade
negative regulation of protein kinase activity
regulation of Ras protein signal transduction
negative regulation of kinase activity
regulation of cellular response to growth factor stimulus
negative regulation of transferase activity
regulation of ERK1 and ERK2 cascade
regulation of MAP kinase activity
regulation of small GTPase mediated signal transduction
negative regulation of protein phosphorylation
focal adhesion
negative regulation of phosphorylation
negative regulation of intracellular signal transduction
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
regulation of transferase activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of protein phosphorylation
regulation of phosphorylation
negative regulation of response to stimulus