SPTB

Entrez Summary: This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009].
UniProt Summary: Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
GSK461364A 0.1μM R03 exp126	-2.68
Cisplatin 0.35μM R06 exp273	1.92

intrinsic component of the cytoplasmic side of the plasma membrane
spectrin
spectrin-associated cytoskeleton
ankyrin binding
actin filament capping
negative regulation of actin filament depolymerization
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
negative regulation of protein depolymerization
negative regulation of protein polymerization
negative regulation of protein complex disassembly
regulation of protein depolymerization
structural constituent of cytoskeleton
regulation of protein complex disassembly
negative regulation of protein complex assembly
negative regulation of supramolecular fiber organization
negative regulation of cytoskeleton organization
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
actin filament binding
endoplasmic reticulum to Golgi vesicle-mediated transport
actin cytoskeleton
regulation of protein polymerization
axon guidance
regulation of actin filament organization
neuron projection guidance
actin binding
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
axonogenesis
MAPK cascade
Golgi vesicle transport
negative regulation of organelle organization
regulation of cellular component size
regulation of actin filament-based process
signal transduction by protein phosphorylation
axon development
cell morphogenesis involved in neuron differentiation
regulation of protein complex assembly