SPTBN5 [The Human Chemical-Genetic Interaction Map Project]

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======= SPTBN5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPTBN5
  * **<color #00a2e8>Official Name</color>**: spectrin beta, non-erythrocytic 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51332|51332]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRC6|Q9NRC6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPTBN5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPTBN5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605916|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spectrin|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myosin tail binding|
|spectrin|
|dynactin binding|
|photoreceptor disc membrane|
|spectrin binding|
|dynein intermediate chain binding|
|actin filament capping|
|filamentous actin|
|negative regulation of actin filament depolymerization|
|photoreceptor connecting cilium|
|kinesin binding|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|protein self-association|
|negative regulation of protein depolymerization|
|negative regulation of protein polymerization|
|negative regulation of protein complex disassembly|
|regulation of protein depolymerization|
|lysosomal transport|
|regulation of protein complex disassembly|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|Golgi organization|
|negative regulation of cytoskeleton organization|
|vacuolar transport|
|microtubule organizing center|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|regulation of protein polymerization|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|actin binding|
|protein homooligomerization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|axonogenesis|
|MAPK cascade|
|Golgi vesicle transport|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|axon development|
|endomembrane system organization|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein complex assembly|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|cell part morphogenesis|
|protein complex oligomerization|
|regulation of cytoskeleton organization|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|neuron projection development|
|negative regulation of cellular component organization|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|neuron differentiation|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.88|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3777
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPTBN5 Expression in NALM6 Cells: 0.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>