SPTBN5
Gene Information
- Official Symbol: SPTBN5
- Official Name: spectrin beta, non-erythrocytic 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 51332
- UniProt: Q9NRC6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Spectrin |
| CH |
GO Terms
| myosin tail binding |
| spectrin |
| dynactin binding |
| photoreceptor disc membrane |
| spectrin binding |
| dynein intermediate chain binding |
| actin filament capping |
| filamentous actin |
| negative regulation of actin filament depolymerization |
| photoreceptor connecting cilium |
| kinesin binding |
| regulation of actin filament depolymerization |
| negative regulation of actin filament polymerization |
| protein self-association |
| negative regulation of protein depolymerization |
| negative regulation of protein polymerization |
| negative regulation of protein complex disassembly |
| regulation of protein depolymerization |
| lysosomal transport |
| regulation of protein complex disassembly |
| negative regulation of protein complex assembly |
| negative regulation of supramolecular fiber organization |
| Golgi organization |
| negative regulation of cytoskeleton organization |
| vacuolar transport |
| microtubule organizing center |
| regulation of actin filament polymerization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| endoplasmic reticulum to Golgi vesicle-mediated transport |
| regulation of protein polymerization |
| axon guidance |
| regulation of actin filament organization |
| neuron projection guidance |
| actin binding |
| protein homooligomerization |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| axonogenesis |
| MAPK cascade |
| Golgi vesicle transport |
| negative regulation of organelle organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| signal transduction by protein phosphorylation |
| axon development |
| endomembrane system organization |
| cell morphogenesis involved in neuron differentiation |
| regulation of protein complex assembly |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| actin cytoskeleton organization |
| regulation of anatomical structure size |
| cell part morphogenesis |
| protein complex oligomerization |
| regulation of cytoskeleton organization |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| actin filament-based process |
| neuron projection development |
| negative regulation of cellular component organization |
| cell morphogenesis |
| neuron development |
| cellular component morphogenesis |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| neuron differentiation |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| phosphorylation |
| regulation of organelle organization |
| locomotion |
| intracellular transport |
| generation of neurons |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| neurogenesis |
| cell development |
| intracellular signal transduction |
| establishment of localization in cell |
| protein-containing complex subunit organization |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nicotinamide 1000μM R03 exp101 | -1.88 |
| Tunicamycin 0.04μM R07 exp418 | 1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3777
- Expression level (log2 read counts): 0.13
Expression Distribution
SPTBN5 Expression in NALM6 Cells: 0.13
