SPTY2D1 [The Human Chemical-Genetic Interaction Map Project]

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======= SPTY2D1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPTY2D1
  * **<color #00a2e8>Official Name</color>**: SPT2 chromatin protein domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=144108|144108]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q68D10|Q68D10]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPTY2D1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPTY2D1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621282|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SPT2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of chromatin assembly|
|RNA polymerase I core binding|
|regulation of chromatin assembly or disassembly|
|histone exchange|
|ATP-dependent chromatin remodeling|
|nucleosome assembly|
|histone binding|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|regulation of chromatin organization|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|DNA conformation change|
|regulation of chromosome organization|
|cellular component|
|chromatin organization|
|cellular protein-containing complex assembly|
|nucleolus|
|regulation of cellular component biogenesis|
|chromosome organization|
|regulation of organelle organization|
|DNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.31|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.19|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.87|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.7|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.7|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.74|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.74|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.76|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.82|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.84|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr3b|POLR3B]]|0.404|
|[[:human genes:m:mllt1|MLLT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18443
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPTY2D1 Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>