SPTY2D1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	-2.31
FBS-Wisent 0.1 R07 exp426	-2.19
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.87
Pifithrin-alpha 20μM R07 exp390	-1.7
Golgicide-A 2μM R03 exp121	1.7
CFI-400945 25μM R08 exp469	1.74
PNU96415E 10μM R03 exp145	1.74
BI-6727 0.04μM R03 exp98	1.76
3-Bromopyruvate 7μM R04 exp175	1.82
UM131593 0.2μM R03 exp106	1.84
2-Methoxyestradiol 0.55μM R07 exp310	1.9

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
POLR3B	0.404
MLLT1	0.4

regulation of chromatin assembly
RNA polymerase I core binding
regulation of chromatin assembly or disassembly
histone exchange
ATP-dependent chromatin remodeling
nucleosome assembly
histone binding
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
DNA packaging
regulation of chromatin organization
protein-DNA complex assembly
protein-DNA complex subunit organization
DNA conformation change
regulation of chromosome organization
cellular component
chromatin organization
cellular protein-containing complex assembly
nucleolus
regulation of cellular component biogenesis
chromosome organization
regulation of organelle organization
DNA binding
protein-containing complex assembly
protein-containing complex subunit organization