SRCIN1 [The Human Chemical-Genetic Interaction Map Project]

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======= SRCIN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRCIN1
  * **<color #00a2e8>Official Name</color>**: SRC kinase signaling inhibitor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80725|80725]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C0H9|Q9C0H9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRCIN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRCIN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610786|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein tyrosine kinase activity|
|regulation of dendritic spine morphogenesis|
|negative regulation of peptidyl-tyrosine phosphorylation|
|substrate adhesion-dependent cell spreading|
|positive regulation of protein tyrosine kinase activity|
|filopodium|
|regulation of dendritic spine development|
|regulation of protein tyrosine kinase activity|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|regulation of dendrite development|
|lamellipodium|
|negative regulation of protein transport|
|cell-substrate adhesion|
|negative regulation of establishment of protein localization|
|positive regulation of peptidyl-tyrosine phosphorylation|
|postsynaptic membrane|
|negative regulation of secretion by cell|
|actin cytoskeleton|
|regulation of synapse organization|
|negative regulation of protein kinase activity|
|regulation of synapse structure or activity|
|negative regulation of secretion|
|protein domain specific binding|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|postsynaptic density|
|synapse|
|negative regulation of transferase activity|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|neuronal cell body|
|negative regulation of protein phosphorylation|
|focal adhesion|
|dendrite|
|negative regulation of phosphorylation|
|protein kinase binding|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|regulation of neuron projection development|
|positive regulation of protein kinase activity|
|cell morphogenesis involved in differentiation|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|negative regulation of protein modification process|
|positive regulation of transferase activity|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of protein transport|
|regulation of cell projection organization|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7300
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRCIN1 Expression in NALM6 Cells: 2.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>