SRCIN1
Gene Information
- Official Symbol: SRCIN1
- Official Name: SRC kinase signaling inhibitor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 80725
- UniProt: Q9C0H9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| negative regulation of protein tyrosine kinase activity |
| regulation of dendritic spine morphogenesis |
| negative regulation of peptidyl-tyrosine phosphorylation |
| substrate adhesion-dependent cell spreading |
| positive regulation of protein tyrosine kinase activity |
| filopodium |
| regulation of dendritic spine development |
| regulation of protein tyrosine kinase activity |
| regulation of dendrite morphogenesis |
| regulation of postsynapse organization |
| negative regulation of protein secretion |
| negative regulation of peptide secretion |
| regulation of dendrite development |
| lamellipodium |
| negative regulation of protein transport |
| cell-substrate adhesion |
| negative regulation of establishment of protein localization |
| positive regulation of peptidyl-tyrosine phosphorylation |
| postsynaptic membrane |
| negative regulation of secretion by cell |
| actin cytoskeleton |
| regulation of synapse organization |
| negative regulation of protein kinase activity |
| regulation of synapse structure or activity |
| negative regulation of secretion |
| protein domain specific binding |
| negative regulation of kinase activity |
| regulation of peptidyl-tyrosine phosphorylation |
| postsynaptic density |
| synapse |
| negative regulation of transferase activity |
| axon |
| regulation of cell morphogenesis involved in differentiation |
| neuronal cell body |
| negative regulation of protein phosphorylation |
| focal adhesion |
| dendrite |
| negative regulation of phosphorylation |
| protein kinase binding |
| regulation of protein secretion |
| negative regulation of transport |
| regulation of cell morphogenesis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| positive regulation of protein kinase activity |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of protein transport |
| regulation of cell projection organization |
| cell morphogenesis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cell migration |
| regulation of kinase activity |
| regulation of cell motility |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| secretion by cell |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| export from cell |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| positive regulation of protein modification process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| generation of neurons |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| cell development |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| regulation of transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7300
- Expression level (log2 read counts): 2.06
Expression Distribution
SRCIN1 Expression in NALM6 Cells: 2.06
