SRF [The Human Chemical-Genetic Interaction Map Project]

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======= SRF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRF
  * **<color #00a2e8>Official Name</color>**: serum response factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6722|6722]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11831|P11831]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600589|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRF-TF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lung smooth muscle development|
|serum response element binding|
|bronchus cartilage development|
|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|
|positive regulation of transcription via serum response element binding|
|positive regulation of transcription by glucose|
|carbon catabolite activation of transcription|
|positive regulation of transcription from RNA polymerase II promoter involved in heart development|
|carbon catabolite regulation of transcription|
|regulation of transcription by glucose|
|RNA polymerase II-specific DNA-binding transcription factor binding|
|cardiac vascular smooth muscle cell differentiation|
|tangential migration from the subventricular zone to the olfactory bulb|
|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|
|trachea cartilage development|
|dorsal aorta morphogenesis|
|negative regulation of amyloid-beta clearance|
|primary miRNA binding|
|dorsal aorta development|
|skin morphogenesis|
|primitive streak formation|
|bronchus development|
|cardiac muscle cell myoblast differentiation|
|positive thymic T cell selection|
|cardioblast differentiation|
|negative regulation of pri-miRNA transcription by RNA polymerase II|
|hematopoietic stem cell differentiation|
|heart trabecula formation|
|eyelid development in camera-type eye|
|regulation of transcription from RNA polymerase II promoter involved in heart development|
|vascular smooth muscle cell differentiation|
|trophectodermal cell differentiation|
|epithelial cell-cell adhesion|
|angiogenesis involved in wound healing|
|regulation of amyloid-beta clearance|
|smooth muscle tissue development|
|contractile actin filament bundle assembly|
|megakaryocyte development|
|stress fiber assembly|
|long-term synaptic depression|
|trachea development|
|platelet formation|
|mRNA transcription by RNA polymerase II|
|thymic T cell selection|
|positive regulation of transcription initiation from RNA polymerase II promoter|
|platelet morphogenesis|
|megakaryocyte differentiation|
|muscle cell cellular homeostasis|
|cell migration involved in sprouting angiogenesis|
|thyroid gland development|
|trabecula formation|
|bone cell development|
|cardiac myofibril assembly|
|mRNA transcription|
|positive regulation of DNA-templated transcription, initiation|
|regulation of water loss via skin|
|positive T cell selection|
|regulation of transcription initiation from RNA polymerase II promoter|
|epithelial structure maintenance|
|gastrulation with mouth forming second|
|branching involved in blood vessel morphogenesis|
|aorta morphogenesis|
|blood vessel endothelial cell migration|
|positive regulation of filopodium assembly|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|positive regulation of smooth muscle contraction|
|regulation of smooth muscle cell differentiation|
|heart trabecula morphogenesis|
|long-term memory|
|erythrocyte development|
|smooth muscle cell differentiation|
|cellular senescence|
|olfactory bulb development|
|olfactory lobe development|
|myoblast differentiation|
|bicellular tight junction assembly|
|regulation of DNA-templated transcription, initiation|
|tight junction assembly|
|blastocyst formation|
|T cell selection|
|tight junction organization|
|regulation of pri-miRNA transcription by RNA polymerase II|
|lung morphogenesis|
|positive regulation of axon extension|
|trabecula morphogenesis|
|apical junction assembly|
|regulation of filopodium assembly|
|coronary vasculature development|
|positive regulation of muscle contraction|
|thymus development|
|sarcomere organization|
|T cell differentiation in thymus|
|face development|
|morphogenesis of an epithelial sheet|
|anterior/posterior axis specification|
|aorta development|
|sprouting angiogenesis|
|telencephalon cell migration|
|myeloid cell development|
|cardiac muscle cell development|
|regulation of smooth muscle contraction|
|heart looping|
|forebrain cell migration|
|artery morphogenesis|
|negative regulation of synaptic transmission|
|actin filament bundle assembly|
|cell aging|
|endothelial cell migration|
|cardiac cell development|
|myofibril assembly|
|actin filament bundle organization|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|multicellular organismal water homeostasis|
|cellular response to nutrient|
|mesoderm formation|
|cellular response to glucose stimulus|
|mesoderm morphogenesis|
|cellular response to hexose stimulus|
|chromatin DNA binding|
|cellular response to monosaccharide stimulus|
|water homeostasis|
|embryonic heart tube development|
|associative learning|
|cellular response to carbohydrate stimulus|
|erythrocyte differentiation|
|hippocampus development|
|epithelial cell migration|
|positive regulation of axonogenesis|
|axis specification|
|artery development|
|epithelium migration|
|hematopoietic progenitor cell differentiation|
|cellular glucose homeostasis|
|cardiac muscle cell differentiation|
|erythrocyte homeostasis|
|tissue migration|
|regulation of axon extension|
|blastocyst development|
|positive regulation of plasma membrane bounded cell projection assembly|
|cellular component assembly involved in morphogenesis|
|cell-cell junction assembly|
|myeloid cell homeostasis|
|limbic system development|
|regulation of extent of cell growth|
|formation of primary germ layer|
|histone deacetylase binding|
|actomyosin structure organization|
|cardiocyte differentiation|
|memory|
|determination of left/right symmetry|
|neuron migration|
|endocrine system development|
|determination of bilateral symmetry|
|specification of symmetry|
|mesoderm development|
|cardiac chamber morphogenesis|
|cell-matrix adhesion|
|branching morphogenesis of an epithelial tube|
|T cell differentiation|
|striated muscle cell development|
|cell-cell junction organization|
|response to glucose|
|platelet activation|
|response to hexose|
|learning|
|response to monosaccharide|
|muscle cell development|
|regulation of muscle cell differentiation|
|positive regulation of cell morphogenesis involved in differentiation|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|gastrulation|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|positive regulation of cell growth|
|morphogenesis of a branching structure|
|cell junction assembly|
|lung development|
|cardiac chamber development|
|positive regulation of developmental growth|
|ameboidal-type cell migration|
|cartilage development|
|response to carbohydrate|
|respiratory tube development|
|pallium development|
|regulation of cell size|
|cell-substrate adhesion|
|glucose homeostasis|
|regulation of axonogenesis|
|carbohydrate homeostasis|
|regulation of synaptic plasticity|
|tissue homeostasis|
|respiratory system development|
|regulation of plasma membrane bounded cell projection assembly|
|bone development|
|homeostasis of number of cells|
|striated muscle cell differentiation|
|regulation of cell projection assembly|
|cell junction organization|
|response to nutrient|
|anterior/posterior pattern specification|
|transcription regulatory region DNA binding|
|myeloid cell differentiation|
|connective tissue development|
|cellular response to nutrient levels|
|T cell activation|
|regulation of muscle system process|
|nuclear chromatin|
|lymphocyte differentiation|
|actin filament organization|
|muscle cell differentiation|
|heart morphogenesis|
|telencephalon development|
|negative regulation of cell migration|
|positive regulation of growth|
|learning or memory|
|positive regulation of DNA-binding transcription factor activity|
|cellular response to extracellular stimulus|
|negative regulation of cell motility|
|aging|
|positive regulation of neuron projection development|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|blood coagulation|
|coagulation|
|muscle tissue development|
|hemostasis|
|cognition|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|camera-type eye development|
|angiogenesis|
|negative regulation of locomotion|
|multicellular organismal homeostasis|
|regulation of developmental growth|
|leukocyte differentiation|
|transcription factor binding|
|regionalization|
|cellular response to external stimulus|
|anatomical structure homeostasis|
|response to hypoxia|
|response to decreased oxygen levels|
|eye development|
|visual system development|
|positive regulation of neuron differentiation|
|sensory system development|
|regulation of cellular component size|
|in utero embryonic development|
|response to oxygen levels|
|positive regulation of cell projection organization|
|lymphocyte activation|
|skin development|
|forebrain development|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|gland development|
|regulation of cell growth|
|sequence-specific DNA binding|
|regulation of DNA-binding transcription factor activity|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|muscle structure development|
|wound healing|
|transcription by RNA polymerase II|
|blood vessel development|
|regulation of cell morphogenesis|
|skeletal system development|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|regulation of neuron projection development|
|response to nutrient levels|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell-cell adhesion|
|response to toxic substance|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|heart development|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cell development|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|response to wounding|
|behavior|
|regulation of system process|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|mRNA metabolic process|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|cellular chemical homeostasis|
|organelle assembly|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|cell activation|
|localization of cell|
|cell motility|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|cytoskeleton organization|
|chemical homeostasis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-3.74|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.95|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.35|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.27|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.1|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.07|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.91|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.8|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.79|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.75|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.73|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.7|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.74|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.84|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.7|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|4.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 32/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|2/26|
|breast|0/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|1/20|
|lung|6/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2209
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRF Expression in NALM6 Cells: 6.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>