SRF
Gene Information
- Official Symbol: SRF
- Official Name: serum response factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 6722
- UniProt: P11831
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.
Pfam Domains GO Terms
Pfam Domains
| SRF-TF |
GO Terms
| lung smooth muscle development |
| serum response element binding |
| bronchus cartilage development |
| positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| positive regulation of transcription via serum response element binding |
| positive regulation of transcription by glucose |
| carbon catabolite activation of transcription |
| positive regulation of transcription from RNA polymerase II promoter involved in heart development |
| carbon catabolite regulation of transcription |
| regulation of transcription by glucose |
| RNA polymerase II-specific DNA-binding transcription factor binding |
| cardiac vascular smooth muscle cell differentiation |
| tangential migration from the subventricular zone to the olfactory bulb |
| regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| trachea cartilage development |
| dorsal aorta morphogenesis |
| negative regulation of amyloid-beta clearance |
| primary miRNA binding |
| dorsal aorta development |
| skin morphogenesis |
| primitive streak formation |
| bronchus development |
| cardiac muscle cell myoblast differentiation |
| positive thymic T cell selection |
| cardioblast differentiation |
| negative regulation of pri-miRNA transcription by RNA polymerase II |
| hematopoietic stem cell differentiation |
| heart trabecula formation |
| eyelid development in camera-type eye |
| regulation of transcription from RNA polymerase II promoter involved in heart development |
| vascular smooth muscle cell differentiation |
| trophectodermal cell differentiation |
| epithelial cell-cell adhesion |
| angiogenesis involved in wound healing |
| regulation of amyloid-beta clearance |
| smooth muscle tissue development |
| contractile actin filament bundle assembly |
| megakaryocyte development |
| stress fiber assembly |
| long-term synaptic depression |
| trachea development |
| platelet formation |
| mRNA transcription by RNA polymerase II |
| thymic T cell selection |
| positive regulation of transcription initiation from RNA polymerase II promoter |
| platelet morphogenesis |
| megakaryocyte differentiation |
| muscle cell cellular homeostasis |
| cell migration involved in sprouting angiogenesis |
| thyroid gland development |
| trabecula formation |
| bone cell development |
| cardiac myofibril assembly |
| mRNA transcription |
| positive regulation of DNA-templated transcription, initiation |
| regulation of water loss via skin |
| positive T cell selection |
| regulation of transcription initiation from RNA polymerase II promoter |
| epithelial structure maintenance |
| gastrulation with mouth forming second |
| branching involved in blood vessel morphogenesis |
| aorta morphogenesis |
| blood vessel endothelial cell migration |
| positive regulation of filopodium assembly |
| positive regulation of pri-miRNA transcription by RNA polymerase II |
| positive regulation of smooth muscle contraction |
| regulation of smooth muscle cell differentiation |
| heart trabecula morphogenesis |
| long-term memory |
| erythrocyte development |
| smooth muscle cell differentiation |
| cellular senescence |
| olfactory bulb development |
| olfactory lobe development |
| myoblast differentiation |
| bicellular tight junction assembly |
| regulation of DNA-templated transcription, initiation |
| tight junction assembly |
| blastocyst formation |
| T cell selection |
| tight junction organization |
| regulation of pri-miRNA transcription by RNA polymerase II |
| lung morphogenesis |
| positive regulation of axon extension |
| trabecula morphogenesis |
| apical junction assembly |
| regulation of filopodium assembly |
| coronary vasculature development |
| positive regulation of muscle contraction |
| thymus development |
| sarcomere organization |
| T cell differentiation in thymus |
| face development |
| morphogenesis of an epithelial sheet |
| anterior/posterior axis specification |
| aorta development |
| sprouting angiogenesis |
| telencephalon cell migration |
| myeloid cell development |
| cardiac muscle cell development |
| regulation of smooth muscle contraction |
| heart looping |
| forebrain cell migration |
| artery morphogenesis |
| negative regulation of synaptic transmission |
| actin filament bundle assembly |
| cell aging |
| endothelial cell migration |
| cardiac cell development |
| myofibril assembly |
| actin filament bundle organization |
| embryonic heart tube morphogenesis |
| determination of heart left/right asymmetry |
| multicellular organismal water homeostasis |
| cellular response to nutrient |
| mesoderm formation |
| cellular response to glucose stimulus |
| mesoderm morphogenesis |
| cellular response to hexose stimulus |
| chromatin DNA binding |
| cellular response to monosaccharide stimulus |
| water homeostasis |
| embryonic heart tube development |
| associative learning |
| cellular response to carbohydrate stimulus |
| erythrocyte differentiation |
| hippocampus development |
| epithelial cell migration |
| positive regulation of axonogenesis |
| axis specification |
| artery development |
| epithelium migration |
| hematopoietic progenitor cell differentiation |
| cellular glucose homeostasis |
| cardiac muscle cell differentiation |
| erythrocyte homeostasis |
| tissue migration |
| regulation of axon extension |
| blastocyst development |
| positive regulation of plasma membrane bounded cell projection assembly |
| cellular component assembly involved in morphogenesis |
| cell-cell junction assembly |
| myeloid cell homeostasis |
| limbic system development |
| regulation of extent of cell growth |
| formation of primary germ layer |
| histone deacetylase binding |
| actomyosin structure organization |
| cardiocyte differentiation |
| memory |
| determination of left/right symmetry |
| neuron migration |
| endocrine system development |
| determination of bilateral symmetry |
| specification of symmetry |
| mesoderm development |
| cardiac chamber morphogenesis |
| cell-matrix adhesion |
| branching morphogenesis of an epithelial tube |
| T cell differentiation |
| striated muscle cell development |
| cell-cell junction organization |
| response to glucose |
| platelet activation |
| response to hexose |
| learning |
| response to monosaccharide |
| muscle cell development |
| regulation of muscle cell differentiation |
| positive regulation of cell morphogenesis involved in differentiation |
| stem cell differentiation |
| morphogenesis of a branching epithelium |
| gastrulation |
| regulation of muscle contraction |
| cardiac muscle tissue development |
| positive regulation of cell growth |
| morphogenesis of a branching structure |
| cell junction assembly |
| lung development |
| cardiac chamber development |
| positive regulation of developmental growth |
| ameboidal-type cell migration |
| cartilage development |
| response to carbohydrate |
| respiratory tube development |
| pallium development |
| regulation of cell size |
| cell-substrate adhesion |
| glucose homeostasis |
| regulation of axonogenesis |
| carbohydrate homeostasis |
| regulation of synaptic plasticity |
| tissue homeostasis |
| respiratory system development |
| regulation of plasma membrane bounded cell projection assembly |
| bone development |
| homeostasis of number of cells |
| striated muscle cell differentiation |
| regulation of cell projection assembly |
| cell junction organization |
| response to nutrient |
| anterior/posterior pattern specification |
| transcription regulatory region DNA binding |
| myeloid cell differentiation |
| connective tissue development |
| cellular response to nutrient levels |
| T cell activation |
| regulation of muscle system process |
| nuclear chromatin |
| lymphocyte differentiation |
| actin filament organization |
| muscle cell differentiation |
| heart morphogenesis |
| telencephalon development |
| negative regulation of cell migration |
| positive regulation of growth |
| learning or memory |
| positive regulation of DNA-binding transcription factor activity |
| cellular response to extracellular stimulus |
| negative regulation of cell motility |
| aging |
| positive regulation of neuron projection development |
| striated muscle tissue development |
| embryonic organ morphogenesis |
| blood coagulation |
| coagulation |
| muscle tissue development |
| hemostasis |
| cognition |
| regulation of cell morphogenesis involved in differentiation |
| epithelial tube morphogenesis |
| negative regulation of cellular component movement |
| camera-type eye development |
| angiogenesis |
| negative regulation of locomotion |
| multicellular organismal homeostasis |
| regulation of developmental growth |
| leukocyte differentiation |
| transcription factor binding |
| regionalization |
| cellular response to external stimulus |
| anatomical structure homeostasis |
| response to hypoxia |
| response to decreased oxygen levels |
| eye development |
| visual system development |
| positive regulation of neuron differentiation |
| sensory system development |
| regulation of cellular component size |
| in utero embryonic development |
| response to oxygen levels |
| positive regulation of cell projection organization |
| lymphocyte activation |
| skin development |
| forebrain development |
| developmental growth |
| growth |
| blood vessel morphogenesis |
| gland development |
| regulation of cell growth |
| sequence-specific DNA binding |
| regulation of DNA-binding transcription factor activity |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| supramolecular fiber organization |
| positive regulation of neurogenesis |
| muscle structure development |
| wound healing |
| transcription by RNA polymerase II |
| blood vessel development |
| regulation of cell morphogenesis |
| skeletal system development |
| actin cytoskeleton organization |
| regulation of body fluid levels |
| regulation of neuron projection development |
| response to nutrient levels |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cell-cell adhesion |
| response to toxic substance |
| vasculature development |
| regulation of anatomical structure size |
| cardiovascular system development |
| positive regulation of cellular component biogenesis |
| heart development |
| response to extracellular stimulus |
| positive regulation of nervous system development |
| positive regulation of cell development |
| sensory organ development |
| cell morphogenesis involved in differentiation |
| hemopoiesis |
| tissue morphogenesis |
| embryonic morphogenesis |
| actin filament-based process |
| response to wounding |
| behavior |
| regulation of system process |
| hematopoietic or lymphoid organ development |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| immune system development |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| tube morphogenesis |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of growth |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| mRNA metabolic process |
| regulation of cell projection organization |
| cell morphogenesis |
| brain development |
| cellular chemical homeostasis |
| organelle assembly |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| protein homodimerization activity |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| response to hormone |
| regulation of cell motility |
| regulation of nervous system development |
| leukocyte activation |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| cell activation |
| localization of cell |
| cell motility |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| cytoskeleton organization |
| chemical homeostasis |
| epithelium development |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| organic cyclic compound biosynthetic process |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| RNA metabolic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 32/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 2/26 |
| breast | 0/33 |
| central nervous system | 4/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 2/21 |
| liver | 1/20 |
| lung | 6/75 |
| lymphocyte | 2/16 |
| ovary | 2/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2209
- Expression level (log2 read counts): 6.27
Expression Distribution
SRF Expression in NALM6 Cells: 6.27
