SRFBP1 [The Human Chemical-Genetic Interaction Map Project]

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======= SRFBP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRFBP1
  * **<color #00a2e8>Official Name</color>**: serum response factor binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=153443|153443]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NEF9|Q8NEF9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRFBP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRFBP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610479|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity). {ECO:0000250|UniProtKB:Q9CZ91}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BUD22|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|90S preribosome|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|perinuclear region of cytoplasm|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.72|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.73|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.73|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.75|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.8|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.8|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.83|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.88|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.95|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cdca3|CDCA3]]|0.445|
|[[:human genes:s:sap30bp|SAP30BP]]|0.442|
|[[:human genes:r:rplp1|RPLP1]]|0.424|
|[[:human genes:n:nol10|NOL10]]|0.417|
|[[:human genes:r:rps7|RPS7]]|0.405|
|[[:human genes:r:rrn3|RRN3]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 342/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|8/28|
|bone|14/26|
|breast|12/33|
|central nervous system|25/56|
|cervix|3/4|
|colorectal|4/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|11/21|
|liver|8/20|
|lung|37/75|
|lymphocyte|6/16|
|ovary|14/26|
|pancreas|7/24|
|peripheral nervous system|7/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|12/22|
|urinary tract|14/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 710
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRFBP1 Expression in NALM6 Cells: 4.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>